Metabolic Comparison of Radiolabeled Bleomycin and Bleomycin-Glucuronide Labeled with 99mTc

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dc.contributor.authorKoçan, F
dc.contributor.authorAvcibasi, U
dc.contributor.authorÜnak, P
dc.contributor.authorMüftüler, FZB
dc.contributor.authorIçhedef, ÇA
dc.contributor.authorDemiroglu, H
dc.contributor.authorGümüser, FG
dc.date.accessioned2025-04-10T10:34:05Z
dc.date.available2025-04-10T10:34:05Z
dc.description.abstractThe metabolic comparison of bleomycin (BLM) and bleomycin-glucuronide (BLMG) radiolabeled with Tc-99m (Tc-99m-BLM and Tc-99m-BLMG, respectively) has been investigated in this study. Quality control procedures were carried out using thin-layer radiochromatography and high-performance liquid chromatography. To compare the metabolic behavior of BLM and its glucuronide conjugate radiolabeled with Tc-99m, scintigraphic, and biodistributional techniques were applied using male New Zealand rabbits and Albino Wistar rats. The results obtained have shown that these compounds were successfully radiolabeled with a labeling yield of about 100%. Maximum uptakes of Tc-99m-BLM and Tc-99m-BLMG metabolized as N-glucuronide were observed within 2 hours in the liver, the bladder, and the spinal cord for Tc-99m-BLM and the lung, the liver, the kidney, the large intestine, and the spinal cord for Tc-99m-BLMG, respectively. Scintigraphy and biodistributional studies performed on the experimental animals have shown that radiopharmaceutical potentials of these compounds are completely different. At the same time, uptake of the Tc-99m-BLMG was found to be better than that of Tc-99m-BLM.
dc.identifier.issn1084-9785
dc.identifier.urihttp://hdl.handle.net/20.500.14701/40274
dc.language.isoEnglish
dc.titleMetabolic Comparison of Radiolabeled Bleomycin and Bleomycin-Glucuronide Labeled with 99mTc
dc.typeArticle

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