Protective effect of alpha lipoic acid on 4-vinylcyclohexene diepoxide induced primary ovarian failure in female rats

Simple item page
dc.contributor.authorÖzel F.
dc.contributor.authorKiray M.
dc.contributor.authorGöker A.
dc.contributor.authorAydemir S.
dc.contributor.authorMıcılı S.C.
dc.date.accessioned2024-07-22T08:07:41Z
dc.date.available2024-07-22T08:07:41Z
dc.date.issued2020
dc.description.abstractObjective: The effects of alpha lipoic acid (ALA) and its possible mechanisms in treating Primary ovarian failure (POF) model was studied with 4 vinylcyclohexene diepoxide (VCD). Material and methods: Rats were divided into 4 groups (n = 7) as Control, VCD, VCD + ALA and ALA. POF model was induced by applying VCD intraperitoneally and ALA was administered by oral gavage as 100 mg/day to the VCD + ALA and ALA groups. Results: At the end of 42 days, ovarian and uterine tissues were received. The number of primordial and primary follicles were increased and corpus luteum and cystic follicles were decreased in ovarian tissues in VCD + ALA group compared to VCD group. Caspase-3 immunoreactivity in follicular cells was decreased in VCD + ALA group compared to VCD group. eNOS immunoreactivity and eNOS levels were decreased in VCD group and increased in VCD + ALA group while iNOS immunoreactivity and iNOS levels were increased in VCD group, decreased in VCD + ALA group in ovary and uterine tissue. Plasma FSH and LH hormone levels were increased in the VCD but decreased in VCD + ALA group. Estradiol level decreased in the VCD group compared to the other groups. The MDA values were significantly increased in the VCD + ALA group compared to VCD group. In addition, the levels of GSH values were decreased in VCD + ALA group compared to VCD group. Conclusion: Alpha lipoic acid treatment of rats with VCD-induced POF had a beneficial effect on reducing ovarian damage by improving histological, immunohistochemical, hormone level and oxidative stress markers. Our results show that ALA is an effective treatment of VCD-induced POF rats. © 2020
dc.identifier.DOI-ID10.1016/j.tjog.2020.01.020
dc.identifier.issn10284559
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/14065
dc.language.isoEnglish
dc.publisherElsevier Ltd
dc.rightsAll Open Access; Gold Open Access
dc.subjectAnimals
dc.subjectAntioxidants
dc.subjectCyclohexenes
dc.subjectFemale
dc.subjectOvary
dc.subjectOxidative Stress
dc.subjectPrimary Ovarian Insufficiency
dc.subjectProtective Agents
dc.subjectRats
dc.subjectThioctic Acid
dc.subjectUterus
dc.subjectVinyl Compounds
dc.subjectcaspase 3
dc.subjectendothelial nitric oxide synthase
dc.subjectestradiol
dc.subjectfollitropin
dc.subjectglutathione
dc.subjectinducible nitric oxide synthase
dc.subjectluteinizing hormone
dc.subjectmalonaldehyde
dc.subjectthioctic acid
dc.subject4-vinyl-1-cyclohexene dioxide
dc.subjectantioxidant
dc.subjectcyclohexene derivative
dc.subjectprotective agent
dc.subjectthioctic acid
dc.subjectvinyl derivative
dc.subjectanimal experiment
dc.subjectanimal model
dc.subjectanimal tissue
dc.subjectArticle
dc.subjectconnective tissue
dc.subjectcontrolled study
dc.subjectcorpus luteum
dc.subjectenzyme analysis
dc.subjectfemale
dc.subjectfollitropin blood level
dc.subjecthistochemistry
dc.subjectimmunoreactivity
dc.subjectluteinizing hormone blood level
dc.subjectnonhuman
dc.subjectovary follicle cell
dc.subjectovary insufficiency
dc.subjectovary tissue
dc.subjectrat
dc.subjectuterus tissue
dc.subjectzona pellucida
dc.subjectanimal
dc.subjectdrug effect
dc.subjectovary
dc.subjectoxidative stress
dc.subjectpremature ovarian failure
dc.subjectuterus
dc.titleProtective effect of alpha lipoic acid on 4-vinylcyclohexene diepoxide induced primary ovarian failure in female rats
dc.typeArticle

Files

Collections

Scopus Koleksiyonu