Topical systems for the controlled release of antineoplastic Drugs: Oxidized Alginate-Gelatin Hydrogel/Unilamellar vesicles

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dc.contributor.authorStagnoli S.
dc.contributor.authorGarro C.
dc.contributor.authorErtekin O.
dc.contributor.authorHeid S.
dc.contributor.authorSeyferth S.
dc.contributor.authorSoria G.
dc.contributor.authorMariano Correa N.
dc.contributor.authorLeal-Egaña A.
dc.contributor.authorBoccaccini A.R.
dc.date.accessioned2024-07-22T08:03:45Z
dc.date.available2024-07-22T08:03:45Z
dc.date.issued2023
dc.description.abstractThe efficacy of chemotherapeutic procedures relies on delivering proper concentrations of anti-cancer drugs in the tumor surroundings, so as to prevent potential side effects on healthy tissues. Novel drug carrier platforms should not just be able to deliver anticancer molecules, but also allow for adjustements in the way these drugs are administered to the patients. We developed a system for delivering water-insoluble drugs, based on the use of 1,2-dioleoyl-sn-glycero-3-phosphocholine (DOPC), or bis(2-ethylhexyl) sulfosuccinate benzyl-n-hexadecyldimethylammonium (BHD-AOT), embedded into oxidized alginate-gelatin (ADA/Gel) hydrogel, emulating a patch for topic applications. After being loaded with curcumin, cancer cells such as human colorectal adenocarcinoma (HCT116 and DLD-1) and melanoma cell lines (MEL501), and non-malignant cells such as mammary epithelial cell lines (NMuMG) and embryonal fibroblasts (NIH 3T3 or NEO cells) were analyzed for biocompatibility and cytotoxic effects. The results show that the proposed system can load comparatively higher concentrations of the drug (with respect to other nano/microcarriers in the literature), and that it can enhance the likelihood of the drug being uptaken by cancer cells instead of non-malignant cells. These assays were complemented by diffusion studies across the stratum corneum of rat skin, with the aim of determining the system's efficiency during topical application. Finally, the stability of the patch was tested after lyophilization to determine its potential pharmaceutical use. As a whole, the combined system represents a highly reliable and robust method for embedding and delivering complex insoluble chemotherapeutical molecules, and it is less invasive than other alternative methods in the literature. © 2022 Elsevier Inc.
dc.identifier.DOI-ID10.1016/j.jcis.2022.08.163
dc.identifier.issn00219797
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/12430
dc.language.isoEnglish
dc.publisherAcademic Press Inc.
dc.subjectAlginates
dc.subjectAnimals
dc.subjectAntineoplastic Agents
dc.subjectDelayed-Action Preparations
dc.subjectDrug Delivery Systems
dc.subjectGelatin
dc.subjectHumans
dc.subjectHydrogels
dc.subjectRats
dc.subjectUnilamellar Liposomes
dc.subjectBiocompatibility
dc.subjectCell culture
dc.subjectCells
dc.subjectControlled drug delivery
dc.subjectDiseases
dc.subjectDrug interactions
dc.subjectHydrogels
dc.subjectMolecules
dc.subjectTargeted drug delivery
dc.subjectalginic acid
dc.subjectbis(2ethylhexyl)sulfosuccinate benzyl n hexadecyldimethylammonium
dc.subjectcurcumin
dc.subjectdioleoylphosphatidylcholine
dc.subjectdocusate sodium
dc.subjectdoxorubicin
dc.subjectdrug carrier
dc.subjectgelatin
dc.subjecthydrogel
dc.subjectnanocarrier
dc.subjectnanochain
dc.subjectunclassified drug
dc.subjectwater
dc.subjectalginic acid
dc.subjectantineoplastic agent
dc.subjectgelatin
dc.subjectliposome
dc.subjectAntineoplastic drugs
dc.subjectCancer cells
dc.subjectCell lines
dc.subjectControled antineoplastic drug release
dc.subjectControlled release
dc.subjectDrug release
dc.subjectMalignant cells
dc.subjectNanocarriers
dc.subjectOxidized alginates
dc.subjectTopical drug delivery systems
dc.subject501-mel cell line
dc.subjectadult
dc.subjectanimal cell
dc.subjectanimal experiment
dc.subjectanimal model
dc.subjectanimal tissue
dc.subjectArticle
dc.subjectbiocompatibility
dc.subjectbiological activity
dc.subjectcomparative study
dc.subjectconcentration process
dc.subjectcontrolled drug release
dc.subjectcontrolled study
dc.subjectcytotoxicity
dc.subjectcytotoxicity assay
dc.subjectDLD-1 cell line
dc.subjectdrug delivery system
dc.subjectdrug release
dc.subjectembedding
dc.subjectfreeze drying
dc.subjectHCT 116 cell line
dc.subjecthuman
dc.subjecthuman cell
dc.subjectimmune response
dc.subjectmale
dc.subjectnanoencapsulation
dc.subjectNIH 3T3 cell line
dc.subjectNmuMG cell line
dc.subjectnonhuman
dc.subjectpharmaceutical care
dc.subjectphysical chemistry
dc.subjectrat
dc.subjectskin
dc.subjectstratum corneum
dc.subjecttreatment duration
dc.subjectanimal
dc.subjectdelayed release formulation
dc.subjectdrug delivery system
dc.subjecthydrogel
dc.subjectpharmacology
dc.subjectprocedures
dc.subjectCancer cells
dc.titleTopical systems for the controlled release of antineoplastic Drugs: Oxidized Alginate-Gelatin Hydrogel/Unilamellar vesicles
dc.typeArticle

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