Mortality-associated factors of candidemia: a multi-center prospective cohort in Turkey

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dc.contributor.authorKutlu M.
dc.contributor.authorSayın-Kutlu S.
dc.contributor.authorAlp-Çavuş S.
dc.contributor.authorÖztürk Ş.B.
dc.contributor.authorTaşbakan M.
dc.contributor.authorÖzhak B.
dc.contributor.authorKaya O.
dc.contributor.authorKutsoylu O.E.
dc.contributor.authorŞenol-Akar Ş.
dc.contributor.authorTurhan Ö.
dc.contributor.authorMermut G.
dc.contributor.authorErtuğrul B.
dc.contributor.authorPullukcu H.
dc.contributor.authorÇetin Ç.B.
dc.contributor.authorAvkan-Oğuz V.
dc.contributor.authorYapar N.
dc.contributor.authorYeşim-Metin D.
dc.contributor.authorErgin Ç.
dc.date.accessioned2024-07-22T08:04:50Z
dc.date.available2024-07-22T08:04:50Z
dc.date.issued2022
dc.description.abstractCandidemia may present as severe and life-threatening infections and is associated with a high mortality rate. This study aimed to evaluate the risk factors associated with 30-day mortality in patients with candidemia. A multi-center prospective observational study was conducted in seven university hospitals in six provinces in the western part of Turkey. Patient data were collected with a structured form between January 2018 and April 2019. In total, 425 episodes of candidemia were observed during the study period. Two hundred forty-one patients died within 30 days, and the 30-day crude mortality rate was 56.7%. Multivariable analysis found that SOFA score (OR: 1.28, CI: 1.154–1.420, p < 0.001), parenteral nutrition (OR: 3.9, CI: 1.752–8.810, p = 0.001), previous antibacterial treatment (OR: 9.32, CI: 1.634–53.744, p = 0.012), newly developed renal failure after candidemia (OR: 2.7, CI: 1.079–6.761, p = 0.034), and newly developed thrombocytopenia after candidemia (OR: 2.6, CI: 1. 057–6.439, p = 0.038) were significantly associated with 30-day mortality. Central venous catheter removal was the only factor protective against mortality (OR: 0.34, CI:0.147–0.768, p = 0.010) in multivariable analysis. Candidemia mortality is high in patients with high SOFA scores, those receiving TPN therapy, and those who previously received antibacterial therapy. Renal failure and thrombocytopenia developing after candidemia should be followed carefully in patients. Antifungal therapy and removing the central venous catheter are essential in the management of candidemia. © 2021, The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.
dc.identifier.DOI-ID10.1007/s10096-021-04394-0
dc.identifier.issn09349723
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/12866
dc.language.isoEnglish
dc.publisherSpringer Science and Business Media Deutschland GmbH
dc.subjectAntifungal Agents
dc.subjectCandida
dc.subjectCandidemia
dc.subjectHumans
dc.subjectProspective Studies
dc.subjectRetrospective Studies
dc.subjectRisk Factors
dc.subjectTurkey
dc.subjectamphotericin B
dc.subjectamphotericin B lipid complex
dc.subjectanidulafungin
dc.subjectantibiotic agent
dc.subjectantifungal agent
dc.subjectcaspofungin
dc.subjectechinocandin
dc.subjectfluconazole
dc.subjectitraconazole
dc.subjectmicafungin
dc.subjectposaconazole
dc.subjectprednisolone
dc.subjectvoriconazole
dc.subjectantifungal agent
dc.subjectadult
dc.subjectaged
dc.subjectantibiotic therapy
dc.subjectantifungal susceptibility
dc.subjectantifungal therapy
dc.subjectArticle
dc.subjectbacteremia
dc.subjectCandida
dc.subjectCandida albicans
dc.subjectCandida endocarditis
dc.subjectCandida endophthalmitis
dc.subjectCandida parapsilosis
dc.subjectcandidemia
dc.subjectcandidiasis
dc.subjectcatheter removal
dc.subjectcohort analysis
dc.subjectcontrolled study
dc.subjectcorticosteroid therapy
dc.subjectcrude mortality rate
dc.subjectdata collection method
dc.subjectdrug substitution
dc.subjectdrug withdrawal
dc.subjectfemale
dc.subjecthuman
dc.subjectkidney failure
dc.subjectmajor clinical study
dc.subjectmale
dc.subjectmortality
dc.subjectmulticenter study
dc.subjectneutropenia
dc.subjectobservational study
dc.subjectodds ratio
dc.subjectparenteral nutrition
dc.subjectpatient coding
dc.subjectprospective study
dc.subjectrisk factor
dc.subjectSequential Organ Failure Assessment Score
dc.subjectthrombocytopenia
dc.subjectTurkey (republic)
dc.subjectuniversity hospital
dc.subjectunspecified side effect
dc.subjectcandidemia
dc.subjectclinical trial
dc.subjectmicrobiology
dc.subjectretrospective study
dc.subjectturkey (bird)
dc.titleMortality-associated factors of candidemia: a multi-center prospective cohort in Turkey
dc.typeArticle

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