Oxytocin and social cognition in patients with schizophrenia: Comparison with healthy siblings and healthy controls

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dc.contributor.authorBalikci K.
dc.contributor.authorAydin O.
dc.contributor.authorTas C.
dc.contributor.authorDanaci A.E.
dc.date.accessioned2024-07-22T08:10:08Z
dc.date.available2024-07-22T08:10:08Z
dc.date.issued2018
dc.description.abstractObjective: There is substantial evidence from animal research indicating a key role of the neuropeptide oxytocin (OT) in the regulation of complex social cognition and behaviour. Social cognition is indispensable for social relationships for the whole of human society, and numerous studies have shown impaired social cognition in schizophrenia (SCH) and unaffected first-degree relatives also seem to be impaired, albeit to a lesser extent. Because of that, this study focuses on the role of OT in social cognition in SCH. Methods: Twenty-seven patients with SCH, 27 healthy siblings (HS) of these patients, and 27 psychologically healthy controls (HC) were included in the study. Blood samples were collected through a peripheral venous catheter. Differences in the socio-demographical and WAIS-R were tested by chi-square and one way-ANOVA. To explore the relationships between social cognition and blood samples we performed Pearson correlations. MANCOVA (gender and WAIS-R as covariates) test was performed to investigate the effect of gender on blood levels of OT and WAIS-R on social cognition. Results: Significant differences were found in neurocognitive and social cognitive capacity but not in OT levels. In the healthy control group, there was a positive correlation between blood OT levels and RMET. There is a statistically significant difference between high and low OT groups with regard to social cognition in all subtests of the RMET. Conclusions: In the current study, we found that patients had deficits in social cognition and neurocognition. Lower endogenous OT levels are also predictive for poor social cognitive functioning in HS and HC. © 2018, The authors.
dc.identifier.DOI-ID10.1080/24750573.2017.1387405
dc.identifier.issn24750573
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/15081
dc.language.isoEnglish
dc.publisherTaylor and Francis Ltd.
dc.rightsAll Open Access; Gold Open Access
dc.subjectchlorpromazine
dc.subjectoxytocin
dc.subjectadult
dc.subjectArticle
dc.subjectbehavior disorder
dc.subjectcase control study
dc.subjectclinical article
dc.subjectcontent validity
dc.subjectcontrolled study
dc.subjectcorrelation analysis
dc.subjectDSM-IV
dc.subjectenzyme linked immunosorbent assay
dc.subjectfemale
dc.subjecthuman
dc.subjectIC50
dc.subjectmale
dc.subjectmultivariate analysis of covariance
dc.subjectobservational study
dc.subjectoxytocin blood level
dc.subjectPositive and Negative Syndrome Scale
dc.subjectpsychiatrist
dc.subjectReading the Mind from the Eyes test
dc.subjectreliability
dc.subjectschizophrenia
dc.subjectsensitivity analysis
dc.subjectsocial cognition
dc.subjectsocial interaction
dc.subjectWechsler adult intelligence scale
dc.subjectWisconsin Card Sorting Test
dc.titleOxytocin and social cognition in patients with schizophrenia: Comparison with healthy siblings and healthy controls
dc.typeArticle

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