Evaluation of the association between null genotypes of glutathione-S-transferases and Behcet's disease

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dc.contributor.authorUzunoǧlu S.
dc.contributor.authorAcar H.
dc.contributor.authorOkudan N.
dc.contributor.authorGökbel H.
dc.contributor.authorMevlitoǧlu I.
dc.contributor.authorSari F.
dc.date.accessioned2024-07-22T08:23:36Z
dc.date.available2024-07-22T08:23:36Z
dc.date.issued2006
dc.description.abstractGlutathione S-transferases (GST) play an important role in oxidative stress related syndromes. An imbalance of the oxidant and antioxidant systems is important in the pathogenesis of Behcet's disease (BD). The objective of this study was to evaluate the association of null genotypes of GST-M1 and GST-T1 with BD since some preliminary molecular genetic data were recently published. Ninety-four Turkish BD patients (42 male, 52 female, 37.1 ± 10.4 years) and 140 healthy volunteers (70 male, 70 female, 36.8 ± 11.7 years) matched for age and gender with the patients as the control group were included in the study. Distributions of GST-M1 and GST-T1 genotypes were determined by multiplexed PCR using three sets of primers for GST-M1, GST-T1, and β-globulin genes. There was no association between BD and the frequencies of GST-M1 and GST-T1 null genotypes when compared to controls by separate analysis. However, by cross and pooled combination analysis there was a significant association between the frequencies of pooled GSTs with one or both null genotypes in BD and controls. This is the first evidence that the association between the frequencies of GST-M1 and GST-T1 null genotypes and BD might be dependent on the interaction of multiple null allele polymorphisms rather than a single null allele of GST-M1 and GST-T1. © Springer-Verlag 2005.
dc.identifier.DOI-ID10.1007/s00403-005-0617-1
dc.identifier.issn03403696
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/19598
dc.language.isoEnglish
dc.subjectAdult
dc.subjectAlleles
dc.subjectAntioxidants
dc.subjectBehcet Syndrome
dc.subjectBeta-Globulins
dc.subjectDNA
dc.subjectFemale
dc.subjectGene Frequency
dc.subjectGenotype
dc.subjectGlutathione Transferase
dc.subjectHumans
dc.subjectMale
dc.subjectMiddle Aged
dc.subjectOxidative Stress
dc.subjectPolymerase Chain Reaction
dc.subjectPolymorphism, Genetic
dc.subjectbeta globulin
dc.subjectglutathione transferase
dc.subjectglutathione transferase M1
dc.subjectglutathione transferase T1
dc.subjectadult
dc.subjectarticle
dc.subjectBehcet disease
dc.subjectcomparative study
dc.subjectcontrolled study
dc.subjectfemale
dc.subjectgene frequency
dc.subjectgene pool
dc.subjectgenetic polymorphism
dc.subjectgenotype
dc.subjecthuman
dc.subjecthuman cell
dc.subjectmajor clinical study
dc.subjectmale
dc.subjectmolecular genetics
dc.subjectnull allele
dc.subjectpolymerase chain reaction
dc.subjectpriority journal
dc.subjectseparation technique
dc.subjectvolunteer
dc.titleEvaluation of the association between null genotypes of glutathione-S-transferases and Behcet's disease
dc.typeArticle

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