The nailfold dermoscopy findings of patients with atypical haemolytic uremic syndrome

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dc.contributor.authorOnder E.N.A.
dc.contributor.authorGokyayla E.
dc.contributor.authorErmertcan A.T.
dc.contributor.authorErtan P.
dc.date.accessioned2024-07-22T08:02:37Z
dc.date.available2024-07-22T08:02:37Z
dc.date.issued2023
dc.description.abstractIntroduction: Hemolytic uremic syndrome (HUS) is a severe disease characterized by microangiopathic anemia, thrombocytopenia, and acute renal failure. Objectives: Atypical HUS (aHUS) that results due to genetic disorders of the alternative complement pathway results in inflammation, endothelial damage, and kidney injury. Therefore, simple and non-invasive tests are needed to evaluate the activity of the disease by assessing the microvascular structure in aHUS. Methods: A dermoscope (×10) is an inexpensive and easily portable device used to visualize nailfold capillaries and has high clinical performance and interobserver reliability. In this study, the nailfold capillaries of patients with aHUS who were in remission under eculizumab treatment were examined, and the findings were compared to those of a healthy control group to evaluate disease characteristics. Results: All children with aHUS had decreased capillary densities even if they were in remission. This may be indicative of ongoing inflammation and microvascular damage in aHUS. Conclusion: A dermoscopy can be used as a screening tool for disease activity in patients with aHUS. © 2023 Elsevier Inc.
dc.identifier.DOI-ID10.1016/j.mvr.2023.104548
dc.identifier.issn00262862
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/11939
dc.language.isoEnglish
dc.publisherAcademic Press Inc.
dc.subjectAtypical Hemolytic Uremic Syndrome
dc.subjectChild
dc.subjectDermoscopy
dc.subjectHumans
dc.subjectInflammation
dc.subjectKidney
dc.subjectReproducibility of Results
dc.subjecteculizumab
dc.subjectadolescent
dc.subjectadult
dc.subjectArticle
dc.subjectcapillary
dc.subjectcapillary density
dc.subjectchild
dc.subjectclinical article
dc.subjectcontrolled study
dc.subjectcost control
dc.subjectdermoscope
dc.subjectdevices
dc.subjectdiagnostic value
dc.subjectdisease activity
dc.subjectepiluminescence microscopy
dc.subjectfemale
dc.subjecthemolytic uremic syndrome
dc.subjecthuman
dc.subjectinflammation
dc.subjectinterrater reliability
dc.subjectmale
dc.subjectmicrovascular damage
dc.subjectmicrovascular structure
dc.subjectmicrovasculature
dc.subjectnailfold capillary
dc.subjectpreschool child
dc.subjectremission
dc.subjectschool child
dc.subjectatypical hemolytic uraemic syndrome
dc.subjectkidney
dc.subjectreproducibility
dc.titleThe nailfold dermoscopy findings of patients with atypical haemolytic uremic syndrome
dc.typeArticle

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