A multicenter study of radiologically isolated syndrome in children and adolescents: Can we predict the course?

dc.contributor.authorYılmaz D.
dc.contributor.authorTeber S.
dc.contributor.authorGültutan P.
dc.contributor.authorYıldırım M.
dc.contributor.authorBektaş Ö.
dc.contributor.authorAlikılıç D.
dc.contributor.authorGüngör M.
dc.contributor.authorKara B.
dc.contributor.authorÖncel İ.
dc.contributor.authorDilek T.D.
dc.contributor.authorSaltık S.
dc.contributor.authorKanmaz S.
dc.contributor.authorYılmaz S.
dc.contributor.authorTekgül H.
dc.contributor.authorÇavuşoğlu D.
dc.contributor.authorKaraoğlu P.
dc.contributor.authorYılmaz Ü.
dc.contributor.authorOrak S.A.
dc.contributor.authorGüngör O.
dc.contributor.authorAnlar B.
dc.date.accessioned2024-07-22T08:02:26Z
dc.date.available2024-07-22T08:02:26Z
dc.date.issued2023
dc.description.abstractObjectives: To evaluate clinical characteristics, imaging features and etiological profile of Radiologically Isolated Syndrome (RIS) along with clinical and radiological follow-up. Methods: Demographic, clinical and radiological data of patients younger than 18 years fulfilling the criteria for RIS were retrospectively analyzed. RIS was defined by the detection of lesions meeting the revised 2010 McDonald Criteria for dissemination in space on magnetic resonance imaging (MRI) in the absence of any symptoms of demyelinating disease or an alternative cause for the MRI findings. Results: There were total 69 patients (38 girls, 31 boys). The median age at index MRI was 15.7 years, and median follow-up time was 28 months. The most common reason for neuroimaging was headache (60.9%). A first clinical event occurred with median 11 months in 14/69 (20%) of cases. Those with oligoclonal bands (OCB) in cerebrospinal fluid (CSF) and follow-up longer than 3 years were more likely to experience a clinical event (p<0.05): 25% of those with OCB manifested clinical symptoms within the first year and 33.3% within the first two years compared to 6.3% and 9.4%, respectively in those without OCB. Radiological evolution was not associated with any variables: age, sex, reason for neuroimaging, serum 25-hydroxyvitamin D level, elevated IgG index, OCB positivity, total number and localization of lesions, presence of gadolinium enhancement, achievement of 2005 criteria for DIS and duration of follow-up. Conclusion: Children and adolescents with RIS and CSF OCB should be followed-up for at least 3 years in order to detect any clinical symptoms suggestive of a demyelinating event. Because disease-modifying treatments are not approved in RIS and no consensus report justifies their use especially in pediatric RIS, close follow-up of OCB-positive patients is needed for early recognition of any clinical event and timely initiation of specific treatment. © 2023 Elsevier B.V.
dc.identifier.DOI-ID10.1016/j.msard.2023.104948
dc.identifier.issn22110348
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/11860
dc.language.isoEnglish
dc.publisherElsevier B.V.
dc.subjectAdolescent
dc.subjectAutoimmune Diseases of the Nervous System
dc.subjectChild
dc.subjectContrast Media
dc.subjectDemyelinating Diseases
dc.subjectFemale
dc.subjectGadolinium
dc.subjectHumans
dc.subjectMagnetic Resonance Imaging
dc.subjectMale
dc.subjectMultiple Sclerosis
dc.subjectOligoclonal Bands
dc.subjectRetrospective Studies
dc.subject25 hydroxyvitamin D
dc.subjectbeta1a interferon
dc.subjectgadolinium
dc.subjectimmunoglobulin G
dc.subjectoligoclonal band
dc.subjectcontrast medium
dc.subjectoligoclonal band
dc.subjectadolescent
dc.subjectArticle
dc.subjectcerebrospinal fluid
dc.subjectchild
dc.subjectclinical feature
dc.subjectclinical outcome
dc.subjectcohort analysis
dc.subjectconsensus
dc.subjectcontrast enhancement
dc.subjectcontrolled study
dc.subjectdata analysis
dc.subjectdemographics
dc.subjectdiagnostic imaging
dc.subjectdisease course
dc.subjectfemale
dc.subjectfollow up
dc.subjectheadache
dc.subjecthealth data
dc.subjecthuman
dc.subjectmajor clinical study
dc.subjectmale
dc.subjectmultiple sclerosis
dc.subjectneuroimaging
dc.subjectneurologic disease
dc.subjectnuclear magnetic resonance imaging
dc.subjectpediatric patient
dc.subjectprediction
dc.subjectradiologically isolated syndrome
dc.subjectradiology
dc.subjectretrospective study
dc.subjectschool child
dc.subjectstudy design
dc.subjectsymptom
dc.subjecttumor localization
dc.subjectvitamin blood level
dc.subjectautoimmune disease of the nervous system
dc.subjectclinical trial
dc.subjectdemyelinating disease
dc.subjectmulticenter study
dc.subjectmultiple sclerosis
dc.titleA multicenter study of radiologically isolated syndrome in children and adolescents: Can we predict the course?
dc.typeArticle

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