Antileishmanial activity of selected Turkish medicinal plants

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dc.contributor.authorOzbilgin A.
dc.contributor.authorDurmuskahya C.
dc.contributor.authorKayalar H.
dc.contributor.authorErtabaklar H.
dc.contributor.authorGunduz C.
dc.contributor.authorUral I.O.
dc.contributor.authorZeyrek F.
dc.contributor.authorKurt O.
dc.contributor.authorCavus I.
dc.contributor.authorBalcıoglu C.
dc.contributor.authorToz S.O.
dc.contributor.authorOzbel Y.
dc.date.accessioned2024-07-22T08:14:36Z
dc.date.available2024-07-22T08:14:36Z
dc.date.issued2014
dc.description.abstractPurpose: To determine the in vitro and in vivo anti-leishmanial activities of extracts obtained from Centaurea calolepis, Phlomis lycia, Eryngium thorifolium, Origanum sipyleum and Galium incanum ssp. centrale.; Methods: To estimate the cytotoxicity of plant extracts, WST-1 assay was used. Parasite inhibition in the presence of plant extracts (25-500 μg/ml) in comparision with control group and reference group (glucantime, 25 μg/ml) at 12-72 h were determined in vitro on L. tropica promastigotes. The in vivo leishmanicidal activity of the extracts was evaluated against L. tropica-infected mice with glucantime as reference drug.; Results: The chloroform extract of Galium incanum ssp. centrale showed the highest cytotoxicity with IC50 value of 0.0316 ± 0.005 μg/ml. In vitro parasite inhibition by the plant extracts ranged between 16.7 ± 0.01 % and 100 ± 0.00 % at 25 μg/ml concentration. The methanol extract of Eryngium thorifolium possessed the highest activity on promastigotes of L. tropica with 100 % inhibition at 25 μg/ml. The water and chloroform extracts of C. calolepis and water and methanol extracts of E. thorifolium at a dose of 100 mg/kg reduced parasitaemia in L. tropica infected mice.; Conclusion: Parasite viability results suggest that the methanol extract of Eryngium thorifolium, regarded as non-cytotoxic, is a promising candidate drug for treating L. tropica infection. © Pharmacotherapy Group, Faculty of Pharmacy, University of Benin, Benin City, 300001 Nigeria. All rights reserved.
dc.identifier.DOI-ID10.4314/tjpr.v13i12.15
dc.identifier.issn15965996
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/16619
dc.language.isoEnglish
dc.publisherUniversity of Benin
dc.rightsAll Open Access; Gold Open Access; Green Open Access
dc.subjectcentaurea calolepis extract
dc.subjecteryngium thorifolium extract
dc.subjectgalium incanum extract
dc.subjectmeglumine antimonate
dc.subjectoriganum sipyleum extract
dc.subjectphlomis lycia extract
dc.subjectplant extract
dc.subjectunclassified drug
dc.subjectanimal experiment
dc.subjectanimal model
dc.subjectanimal tissue
dc.subjectantileishmanial activity
dc.subjectantiprotozoal activity
dc.subjectArticle
dc.subjectcontrolled study
dc.subjectcytotoxicity
dc.subjectfemale
dc.subjectIC50
dc.subjectleishmaniasis
dc.subjectmouse
dc.subjectnonhuman
dc.subjectpromastigote
dc.subjectskin leishmaniasis
dc.subjectskull injury
dc.subjectWST-1 assay
dc.titleAntileishmanial activity of selected Turkish medicinal plants
dc.typeArticle

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