Assessment of in-vitro cytotoxicity and in-ovo virucidal antiviral efficacy of various plant extracts and bioactive molecules

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dc.contributor.authorÇöven F.O.
dc.contributor.authorGür S.
dc.contributor.authorUyar E.
dc.contributor.authorAlsakini K.A.M.H.
dc.contributor.authorKarabey F.
dc.contributor.authorÇöven F.
dc.contributor.authorÇaliş İ.
dc.contributor.authorNalbantsoy A.
dc.date.accessioned2024-07-22T08:01:49Z
dc.date.available2024-07-22T08:01:49Z
dc.date.issued2024
dc.description.abstractThe viral diseases that occurred in recent years have increased the interest in non-toxic to healthy cells and naturally isolated agents to struggle with these diseases. The key intention of this research is to examine both antiviral potentials against the Infectious Bronchitis model virus (IBV) and cytotoxic activities on determined cell lines of different active ingredients and medical herbs extracts for developing new antiviral agents or drugs towards SARS-CoV-2. The antiviral potency of the samples against IBV was determined as in ovo virucidal antiviral activity in specific pathogen-free (SPF) embryonated chicken eggs (ECEs). To detect antiviral activity, the haemagglutination test was performed after 48 h of incubation for all samples. The cytotoxic activity of the samples was identified on HepG2, Caco-2, HeLa, HEK293, PANC-1, PC-3, A549, MDA-MB-231, and CCD-34Lu cell lines by the MTT protocol. Hypericum perforatum extract was found to have a dominant role in cytotoxicity and antiviral activity. In addition, while nobiletin and Sambucus nigra do not exhibit cytotoxic activity on cells, they play a significant role in antiviral activity. As a consequence of our investigation, the cytotoxic and antiviral properties of Laurus nobilis, H. perforatum, and S. nigra extracts were found remarkable and the potential of these extracts was demonstrated. © 2024, Veteriner Fakultesi Dergisi. All rights reserved.
dc.identifier.DOI-ID10.9775/kvfd.2023.30306
dc.identifier.issn13006045
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/11581
dc.language.isoEnglish
dc.publisherVeteriner Fakultesi Dergisi
dc.rightsAll Open Access; Gold Open Access
dc.subjectdoxorubicin
dc.subjectEchinacea purpurea extract
dc.subjectfavipiravir
dc.subjectgallic acid
dc.subjectHypericum perforatum extract
dc.subjectMelissa officinalis extract
dc.subjectneohesperidin
dc.subjectnobiletin
dc.subjectoleuropein
dc.subjectSambucus nigra extract
dc.subjectsinecatechins
dc.subjecttangeretin
dc.subjectA-549 cell line
dc.subjectanimal experiment
dc.subjectantiviral activity
dc.subjectArticle
dc.subjectCaco-2 cell line
dc.subjectchorioallantois
dc.subjectcontrolled study
dc.subjectcytotoxicity
dc.subjectHEK293 cell line
dc.subjectHeLa cell line
dc.subjecthemagglutination test
dc.subjectHep-G2 cell line
dc.subjectHLF cell line (lung fibroblast)
dc.subjecthuman
dc.subjecthuman cell
dc.subjecthuman experiment
dc.subjectIC50
dc.subjectin vitro study
dc.subjectLaurus nobilis
dc.subjectMDA-MB-231 cell line
dc.subjectMTT assay
dc.subjectnonhuman
dc.subjectnormal human
dc.subjectPANC-1 cell line
dc.subjectPC-3 [Human prostate carcinoma] cell line
dc.subjectvirucidal activity
dc.titleAssessment of in-vitro cytotoxicity and in-ovo virucidal antiviral efficacy of various plant extracts and bioactive molecules
dc.typeArticle

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