Synthesis and characterization of chloralose-derived thiosemicarbazones and semicarbazones and investigation of their antimicrobial properties
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2014
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Abstract
Thiosemicarbazones(7-10)/semicarbazones(11-14) were synthesized in good yields via the condensation of α-gluco-, β-gluco-, galacto-, manno- chloralose derived 1,4-furanodialdoses (1-4) with thiosemicarbazide(5)/ semicarbazide(6). The structures of all products were characterized by FTIR, NMR spectroscopic methods and elemental analysis. The compounds have been found to display moderate antimicrobial activity against Gram-positive, Gram-negative bacteria and antifungal activity against a Candida albicans. MIC values of the compounds range from 260 to 1510 g/mL. © 2014 Taylor & Francis Group, LLC.