Long-term effect of pentoxifylline and NG-nitro-L-arginine methyl ester on testicular function in spermatic artery ligation

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dc.contributor.authorYilmaz O.
dc.contributor.authorGenc A.
dc.contributor.authorTaneli F.
dc.contributor.authorDemireli P.
dc.contributor.authorKocakoc I.D.
dc.contributor.authorSencan A.
dc.contributor.authorGunsar C.
dc.contributor.authorMir E.
dc.contributor.authorTaneli C.
dc.date.accessioned2024-07-22T08:23:42Z
dc.date.available2024-07-22T08:23:42Z
dc.date.issued2006
dc.description.abstractObjective. To investigate long-term testicular function in pentoxifylline- and NG-nitro-L-arginine methyl ester (L-NAME)-treated rats prior to spermatic artery ligation by assessing serum inhibin B concentration, a reliable endocrine marker of spermatogenesis. Material and methods. Forty prepubertal rats were randomly divided into four equal groups. Right orchiectomy was performed in all rats. Intraperitoneal pentoxifylline and L-NAME were administered to Groups 1 and 2, respectively. Rats in Group 3 did not receive any medication. The spermatic arteries of the left testes were ligated in all groups with the exception of the sham controls (Group 4). One month postoperatively, a histopathologic evaluation was performed and serum inhibin B concentrations were assessed in all groups. Results. There were no statistically significant differences in testis size or serum inhibin B concentration between Groups 1, 2 and 3. However, the testes were significantly smaller (p1=0.01, p2=0.01, p3 =0.01) and serum inhibin B levels were significantly decreased (p1=0.01, p2 =0.01, p3 =0.01) when Groups 1-3 were compared with Group 4. Histopathological evaluations revealed necrosis and calcification in all specimens with the exception of the sham-operated group. Conclusions. The long-term outcomes of spermatic artery ligation were poor and testicular atrophy developed in rat testes in all study groups. Testicular atrophy could not be reversed by preoperative administration of pentoxifylline and L-NAME. © 2006 Taylor & Francis.
dc.identifier.DOI-ID10.1080/00365590500329627
dc.identifier.issn16512065
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/19661
dc.language.isoEnglish
dc.subjectAnimals
dc.subjectBiopsy, Needle
dc.subjectDisease Models, Animal
dc.subjectImmunohistochemistry
dc.subjectLigation
dc.subjectMale
dc.subjectNG-Nitroarginine Methyl Ester
dc.subjectOrchiectomy
dc.subjectPentoxifylline
dc.subjectProbability
dc.subjectRandom Allocation
dc.subjectRats
dc.subjectRats, Wistar
dc.subjectReference Values
dc.subjectRisk Factors
dc.subjectSensitivity and Specificity
dc.subjectSpermatic Cord
dc.subjectSpermatogenesis
dc.subjectStatistics, Nonparametric
dc.subjectTestis
dc.subjectinhibin B
dc.subjectn(g) nitroarginine methyl ester
dc.subjectpentoxifylline
dc.subjectanimal experiment
dc.subjectanimal tissue
dc.subjectartery ligation
dc.subjectarticle
dc.subjectcalcification
dc.subjectcontrolled study
dc.subjecthistopathology
dc.subjecthormone blood level
dc.subjectmale
dc.subjectnecrosis
dc.subjectnonhuman
dc.subjectorchiectomy
dc.subjectprepuberty
dc.subjectpriority journal
dc.subjectrat
dc.subjectspermatic artery ligation
dc.subjectspermatogenesis
dc.subjectstatistical significance
dc.subjecttestis
dc.subjecttestis atrophy
dc.subjecttestis function
dc.subjecttestis size
dc.titleLong-term effect of pentoxifylline and NG-nitro-L-arginine methyl ester on testicular function in spermatic artery ligation
dc.typeArticle

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