Sensitization to cat allergens in non-cat owner patients with respiratory allergy

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dc.contributor.authorGulbahar O.
dc.contributor.authorSin A.
dc.contributor.authorMete N.
dc.contributor.authorKokuludag A.
dc.contributor.authorKirmaz C.
dc.contributor.authorSebik F.
dc.date.accessioned2024-07-22T08:24:46Z
dc.date.available2024-07-22T08:24:46Z
dc.date.issued2003
dc.description.abstractBackground: Cats represent one of the most important sources of indoor allergens. The sensitization rate can reach up to 60% in western countries. Keeping cats indoors is uncommon in big cities in Turkey, but cats living in the streets are common. Objective: To investigate the prevalence of sensitization to cats in patients with respiratory allergy from Izmir, Turkey, and its relationship to home cat allergen levels. Methods: A total of 387 patients (70.8% female; mean age, 34.3 years) with respiratory allergic diseases (rhinitis and/or asthma) were included in this study. Skin prick test to cat was performed. House dust samples were collected from the living room of 25 patients and 14 healthy subjects. The major cat allergen (Fel d 1) levels were measured by Dustscreen. Fel d 1 levels given by the manufacturer were as follows: 0.05, 0.13, 0.40, 1.1, and 6.2 mU/mL. Results: The prevalence of cat sensitivity was 44.7% (n = 173). Only 6 patients (1.6%) had a history of feeding a cat in their houses. Thirty-six (92%) of 39 houses had detectable levels of cat allergen (mean Fel d 1 level, 2.24 ± 2.69 mU/mL). The mean Fel d 1 levels were 1.58 ± 2.51 mU/mL in the healthy group, 1.91 ± 2.61 mU/mL in the asthmatic group, and 3.26 ± 2.85 mU/mL in the group with allergic rhinitis (P = 0.12). The prevalence of cat sensitivity in patients who had 1.1 mU/mL of Fel d 1 in their homes was 57.1%. This rate was five times lower (11.1%) in patients who had the highest Fel d 1 level (6.2 mU/mL) in their homes. Conclusions: The prevalence of cat sensitivity in Izmir, where cats are generally not kept within homes, is as high as in western countries. The sampled houses have measurable levels of Fel d 1 even in the absence of indoor cats. High prevalence of cat sensitivity in Izmir is probably due to indirect exposure.
dc.identifier.DOI-ID10.1016/S1081-1206(10)61868-6
dc.identifier.issn10811206
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/20119
dc.language.isoEnglish
dc.publisherAmerican College of Allergy, Asthma and Immunology
dc.subjectallergen
dc.subjectcat allergen
dc.subjectunclassified drug
dc.subjectadult
dc.subjectallergic rhinitis
dc.subjectarticle
dc.subjectasthma
dc.subjectcat
dc.subjectcontrolled study
dc.subjectdomestic animal
dc.subjectenvironmental exposure
dc.subjectfemale
dc.subjecthome
dc.subjecthouse dust
dc.subjecthuman
dc.subjectmajor clinical study
dc.subjectmale
dc.subjectmeasurement
dc.subjectprevalence
dc.subjectprick test
dc.subjectpriority journal
dc.subjectrespiratory tract allergy
dc.subjectsensitization
dc.subjectskin test
dc.subjectTurkey (republic)
dc.titleSensitization to cat allergens in non-cat owner patients with respiratory allergy
dc.typeArticle

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