Effects of octreotide and propranolol on colonic mucosa in rats with portal hypertensive colopathy

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dc.contributor.authorAydede H.
dc.contributor.authorSakarya A.
dc.contributor.authorErhan Y.
dc.contributor.authorKara E.
dc.contributor.authorIlkgul O.
dc.contributor.authorOzdemir N.
dc.date.accessioned2024-07-22T08:24:43Z
dc.date.available2024-07-22T08:24:43Z
dc.date.issued2003
dc.description.abstractBackground/Aims: The aim of the study is to clarify the effects of octreotide and propranolol, agents used in the treatment of portal hypertension, on mucosal changes in portal hypertensive colopathy. Methodology: Portal hypertension was induced in all rats by partial portal vein ligation, and after the operation all rats were caged for a 10-week period. Then, animals were divided into three groups and for two weeks medical treatment were administered to the individual groups as follows: Control group, saline 0.5mL/day, intraperitoneally. Octreotide group, octreotide 100μg/kg/12 hours, subcutaneously. Propranolol group, propranolol 20mg/kg/day, intraperitoneally. In order to assess the portal hypertensive colopathy, criteria such as mean diameters of dilated vessels in colonic mucosa, and the existence of mucosal edema, capillary ectasia, hyperemia and hemorrhage, inflammation were used. Results: When parameters were compared for the control versus propranolol groups, mucosal edema and hyperemia and hemorrhage criteria were found to be significant for the propranolol group; control versus octreotide groups, mucosal edema, capillary ectasia, and hyperemia and hemorrhage criteria were found to be significant for the octreotide group; octreotide versus propranolol groups, capillary ectasia and mucosal edema criteria were found to be significant for the octreotide group. Conclusions: The mucosal changes in portal hypertensive colopathy could be corrected by drugs modifying portal blood flow, octreotide may find a place in the treatment of portal hypertensive colopathy.
dc.identifier.issn01726390
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/20084
dc.language.isoEnglish
dc.subjectAnimals
dc.subjectAntihypertensive Agents
dc.subjectGastrointestinal Agents
dc.subjectHypertension, Portal
dc.subjectIntestinal Mucosa
dc.subjectMale
dc.subjectOctreotide
dc.subjectPortal System
dc.subjectPropranolol
dc.subjectRats
dc.subjectRats, Inbred Strains
dc.subjectRegional Blood Flow
dc.subjectoctreotide
dc.subjectpropranolol
dc.subjectanimal experiment
dc.subjectanimal model
dc.subjectanimal tissue
dc.subjectarticle
dc.subjectcolitis
dc.subjectcolon disease
dc.subjectcolon hemorrhage
dc.subjectcolon mucosa
dc.subjectcontrolled study
dc.subjectdrug effect
dc.subjectedema
dc.subjecthistopathology
dc.subjecthyperemia
dc.subjectmale
dc.subjectnonhuman
dc.subjectportal hypertension
dc.subjectpriority journal
dc.subjectrat
dc.titleEffects of octreotide and propranolol on colonic mucosa in rats with portal hypertensive colopathy
dc.typeArticle

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