Characterization of Polymeric Microneedle Arrays for Transdermal Drug Delivery

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dc.contributor.authorDemir Y.K.
dc.contributor.authorAkan Z.
dc.contributor.authorKerimoglu O.
dc.date.accessioned2024-07-22T08:18:05Z
dc.date.available2024-07-22T08:18:05Z
dc.date.issued2013
dc.description.abstractMicrofabrication of dissolvable, swellable, and biodegradable polymeric microneedle arrays (MNs) were extensively investigated based in a nano sensitive fabrication style known as micromilling that is then combined with conventional micromolding technique. The aim of this study was to describe the polymer selection, and optimize formulation compounding parameters for various polymeric MNs. Inverse replication of micromilled master MNs reproduced with polydimethylsiloxane (PDMS), where solid out of plane polymeric MNs were subsequently assembled, and physicochemically characterized. Dissolvable, swellable, and biodegradable MNs were constructed to depth of less than 1 mm with an aspect ratio of 3.6, and 1/2 mm of both inter needle tip and base spacing. Micromolding step also enabled to replicate the MNs very precisely and accurate. Polymeric microneedles (MN) precision was ranging from ±0.18 to ±1.82% for microneedle height, ±0.45 to ±1.42% for base diameter, and ±0.22 to ±0.95% for interbase spacing. Although dissolvable sodium alginate MN showed less physical robustness than biodegradable polylactic-co-glycolic acid MN, their thermogravimetric analysis is of promise for constructing these polymeric types of matrix devices. © 2013 Demir et al.
dc.identifier.DOI-ID10.1371/journal.pone.0077289
dc.identifier.issn19326203
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/17181
dc.language.isoEnglish
dc.rightsAll Open Access; Gold Open Access
dc.subjectAdministration, Cutaneous
dc.subjectAnalysis of Variance
dc.subjectBiocompatible Materials
dc.subjectCalorimetry, Differential Scanning
dc.subjectDimethylpolysiloxanes
dc.subjectDrug Delivery Systems
dc.subjectMaterials Testing
dc.subjectMicroscopy, Electron, Scanning
dc.subjectMicrotechnology
dc.subjectNeedles
dc.subjectThermogravimetry
dc.subjectalginic acid
dc.subjectchitosan
dc.subjectdimeticone
dc.subjecthydroxypropylcellulose
dc.subjectpolyglactin
dc.subjectpolymer
dc.subjectpolyvinyl alcohol
dc.subjectbaysilon
dc.subjectbiomaterial
dc.subjectaccuracy
dc.subjectarticle
dc.subjectbiodegradability
dc.subjectmicroneedle
dc.subjectmicrotechnology
dc.subjectphysical chemistry
dc.subjectsolubility
dc.subjectthermogravimetry
dc.subjecttransdermal drug administration
dc.subjectanalysis of variance
dc.subjectdevices
dc.subjectdifferential scanning calorimetry
dc.subjectdrug delivery system
dc.subjectintradermal drug administration
dc.subjectmaterials testing
dc.subjectneedle
dc.subjectprocedures
dc.subjectscanning electron microscopy
dc.titleCharacterization of Polymeric Microneedle Arrays for Transdermal Drug Delivery
dc.typeArticle

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