Is there a vicious cycle between obstructive sleep apnea and laryngopharyngeal reflux disease?

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dc.contributor.authorEskiizmir G.
dc.contributor.authorKezirian E.
dc.date.accessioned2024-07-22T08:21:30Z
dc.date.available2024-07-22T08:21:30Z
dc.date.issued2009
dc.description.abstractObstructive sleep apnea (OSA) is a common sleep-related breathing disorder which is mainly characterized by the repetitive episodes of obstructive apneas and/or hypopneas. It is associated with daytime sleepiness, decrements in quality of life, cardiovascular and cerebrovascular diseases and endocrine disturbances. In addition, there is a high prevalence of gastric reflux (including both gastroesophageal reflux and laryngopharyngeal reflux diseases) in patients with OSA. However, the mechanism underlying this association has not been completely established. Herein, we hypothesize that there is a vicious cycle between OSA and laryngopharyngeal reflux disease. Increased respiratory efforts in OSA generate more-negative intrathoracic pressure, contributing to reflux of gastric contents, which in turn creates inflammation and sensory deficits in the laryngeal and pharyngeal tissues that contributes to progression of OSA through both inflammatory and neuromuscular pathways. © 2009 Elsevier Ltd.
dc.identifier.DOI-ID10.1016/j.mehy.2009.04.042
dc.identifier.issn03069877
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/18649
dc.language.isoEnglish
dc.subjectHumans
dc.subjectModels, Theoretical
dc.subjectRegurgitation, Gastric
dc.subjectSleep Apnea Syndromes
dc.subjectairway obstruction
dc.subjectarousal
dc.subjectarticle
dc.subjectcardiovascular disease
dc.subjectcerebrovascular disease
dc.subjectdaytime somnolence
dc.subjectdisease association
dc.subjectdisease course
dc.subjectendocrine disease
dc.subjectgastroesophageal reflux
dc.subjecthuman
dc.subjecthypothesis
dc.subjectinflammation
dc.subjectlaryngopharyngeal reflux
dc.subjectpriority journal
dc.subjectquality of life
dc.subjectsensory dysfunction
dc.subjectsleep apnea syndrome
dc.subjectthorax pressure
dc.titleIs there a vicious cycle between obstructive sleep apnea and laryngopharyngeal reflux disease?
dc.typeArticle

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