Effects of isotretinoin on spermatogenesis of rats

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dc.contributor.authorGencoglan G.
dc.contributor.authorTosun M.
dc.date.accessioned2024-07-22T08:20:24Z
dc.date.available2024-07-22T08:20:24Z
dc.date.issued2011
dc.description.abstractBackground: The results of studies on the effects of retinoids on spermatogenesis are controversial. Objectives: We evaluated time- and dose-dependent effects of isotretinoin on spermatogenic activity by apoptosis, cyclin D1, E2F, p53 expressions, and Johnsen's scores. Methods: The rats were divided into three groups. In the 1st group (n=18), 1mg/mL/day and in the 2nd group (n=18) 2mg/mL/day isotretinoin were administered for 21 days. Flower oil was given to the 3rd (n=6) control group. On the 7th (groups 1a and 2a), 14th (groups 1b and 2b), and 21st (groups 1c and 2c) days, six rats from the 1st group and six rats from the 2nd group were sacrificed and bilateral orchiectomy was done. Results: The number of cyclin D1 and E2F-positive cells decreased nonsignificantly parallel to days in the 1st group, whereas there was a statistically significant decrease in the 2nd group for the same cells. The p53-positive cells in groups 1c and 2c were increased significantly. Conclusions: Further studies on the effects of retinoids on spermatogenesis should be conducted. It may be wise to administer contraception to male patients, especially during high-dose and long-term retinoid therapy. © 2011 Informa Healthcare USA, Inc.
dc.identifier.DOI-ID10.3109/15569527.2010.521537
dc.identifier.issn15569535
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/18143
dc.language.isoEnglish
dc.subjectAnimals
dc.subjectApoptosis
dc.subjectCyclin D1
dc.subjectDermatologic Agents
dc.subjectDose-Response Relationship, Drug
dc.subjectE2F Transcription Factors
dc.subjectIsotretinoin
dc.subjectMale
dc.subjectRats
dc.subjectRats, Sprague-Dawley
dc.subjectSeminiferous Tubules
dc.subjectSpermatogenesis
dc.subjectTestis
dc.subjectTime Factors
dc.subjectTumor Suppressor Protein p53
dc.subjectRattus
dc.subjectcyclin D1
dc.subjectisotretinoin
dc.subjectprotein p53
dc.subjectsafflower oil
dc.subjecttranscription factor E2F
dc.subjectanimal cell
dc.subjectanimal experiment
dc.subjectanimal tissue
dc.subjectapoptosis
dc.subjectarticle
dc.subjectcontrolled study
dc.subjectmale
dc.subjectnonhuman
dc.subjectorchiectomy
dc.subjectprotein expression
dc.subjectrat
dc.subjectscoring system
dc.subjectspermatogenesis
dc.titleEffects of isotretinoin on spermatogenesis of rats
dc.typeArticle

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