The trefoil factor family 1 (TFF-1) and 3 (TFF-3) are upregulated in the saliva, gingival crevicular fluid and serum of periodontitis patients
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Date
2022
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Abstract
Objective: This study aimed to investigate the levels of trefoil factor family (TFF)-1, TFF-3 and interleukin (IL)-1β in gingival crevicular fluid (GCF), saliva and serum of patients with gingivitis, stage 3 periodontitis and healthy individuals. Materials and Methods: A total of 100 individuals consisting of 25 periodontally healthy, 25 gingivitis and 50 stage 3 periodontitis, were enrolled in the study. Clinical periodontal examinations were recorded and GCF, saliva and serum samples were obtained. TFF-1, TFF-3 and IL-1β were measured by ELISA. Results: TFF-1 and TFF-3 levels in both GCF, saliva and serum were higher in periodontitis patients than healthy controls (p <.001) and gingivitis group (p <.01). The levels of these peptides in all biofluids were similar between gingivitis and healthy control groups (p >.05). GCF, saliva and serum IL-1β levels were also higher in periodontitis patients than the controls (p <.01). Periodontitis patients had elevated GCF and saliva IL-β levels than gingivitis group (p <.001). Conclusion: Elevated TFF-1 and TFF-3 levels both locally and systemically in periodontitis in parallel to increased IL-1β levels might suggest that these peptides are involved in host response during the periodontal tissue destruction. © 2021 Wiley Periodicals LLC.
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Chronic Periodontitis , Gingival Crevicular Fluid , Gingivitis , Humans , Saliva , Trefoil Factors , interleukin 1beta , trefoil factor 1 , trefoil factor 3 , trefoil factor , adult , Article , biochemical analysis , bleeding on probing , blood sampling , body fluid , clinical attachment level , clinical evaluation , clinical examination , controlled study , enzyme linked immunosorbent assay , female , gingival index , gingival tissue , gingivitis , human , human tissue , immune response , major clinical study , male , medical history , non-smoker , periodontal examination , periodontal pocket depth , periodontitis , plaque index , protein blood level , radiodiagnosis , saliva level , sampling , Turkey (republic) , upregulation , chronic periodontitis , gingivitis , saliva