Evaluation of 131I-Pentamidine for scintigraphy of experimentally Leishmania tropica-infected hamsters

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dc.contributor.authorInceboz T.
dc.contributor.authorLambrecht F.Y.
dc.contributor.authorEren M.Ş.
dc.contributor.authorGirginkardeşler N.
dc.contributor.authorBekiş R.
dc.contributor.authorYilmaz O.
dc.contributor.authorEr Ö.
dc.contributor.authorÖzbilgin A.
dc.date.accessioned2024-07-22T08:17:17Z
dc.date.available2024-07-22T08:17:17Z
dc.date.issued2014
dc.description.abstractWe aimed to assess the ability of 131I-Pentamidine scintigraphy to detect the lesions of Leishmania tropica infection. An experimental model of cutaneous leishmaniasis was developed. The presence of cutaneous leishmaniasis was confirmed. Pentamidine was radioiodinated with 131I. The radiolabeled pentamidine was validated by the requisite quality control tests to check its radiolabeling efficiency, in vitro stability. 131I- Pentamidine (activity: 18.5 MBq/100 l) was injected intracardiacally into infected hamsters. Static whole body images of the hamsters were acquired under the gamma camera at 5 and 30 in, 2, 6 and 24 h following the administration. On the scintigrams, anatomically adjusted regions of interest (ROIs) were drawn over the right feet (target) and left feet (not-target) and various organs. Accumulation of 131I-Pentamidine at sites of infection is expressed as the target to non-target (T/NT) ratio. The results T/NT ratio decreased with time. In concluding the 131I-Pentamidine has poor sensitivity in detection of L. tropica infection. © 2014 Informa UK Ltd. All rights reserved: reproduction in whole or part not permitted.
dc.identifier.DOI-ID10.3109/1061186X.2013.878943
dc.identifier.issn1061186X
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/17016
dc.language.isoEnglish
dc.publisherInforma Healthcare
dc.subjectAnimals
dc.subjectDisease Models, Animal
dc.subjectIodine Radioisotopes
dc.subjectLeishmania tropica
dc.subjectLeishmaniasis, Cutaneous
dc.subjectMale
dc.subjectMesocricetus
dc.subjectPentamidine
dc.subjectTissue Distribution
dc.subjectTrypanocidal Agents
dc.subjectWhole Body Imaging
dc.subjectpentamidine
dc.subjectpentamidine iodine 131
dc.subjectradiopharmaceutical agent
dc.subjectunclassified drug
dc.subjectantitrypanosomal agent
dc.subjectpentamidine
dc.subjectradioactive iodine
dc.subjectanimal experiment
dc.subjectanimal model
dc.subjectarticle
dc.subjectcontrolled study
dc.subjectgamma camera
dc.subjecthamster
dc.subjectisotope labeling
dc.subjectLeishmania tropica
dc.subjectmale
dc.subjectmicroscopy
dc.subjectnonhuman
dc.subjectpriority journal
dc.subjectquality control
dc.subjectscintigraphy
dc.subjectskin leishmaniasis
dc.subjectthin layer chromatography
dc.subjectanimal
dc.subjectchemistry
dc.subjectdiagnostic use
dc.subjectdisease model
dc.subjectdrug effects
dc.subjectisolation and purification
dc.subjectMesocricetus
dc.subjectparasitology
dc.subjectscintiscanning
dc.subjectskin leishmaniasis
dc.subjecttissue distribution
dc.subjectwhole body imaging
dc.titleEvaluation of 131I-Pentamidine for scintigraphy of experimentally Leishmania tropica-infected hamsters
dc.typeArticle

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