Therapeutic Hotline: Treatment of prurigo nodularis and lichen simplex chronicus with gabapentin
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Date
2010
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Abstract
Psychocutaneous conditions are frequently encountered in dermatology practice. Prurigo nodularis and lichen simplex chronicus are two frustrating conditions that are classified in this category. They are often refractory to classical treatment with topical corticosteroids and antihistamines. Severe, generalized exacerbations require systemic therapy. Phototherapy, erythromycine, retinoids, cyclosporine, azathiopurine, naltrexone, and psychopharmacologic agents (pimozide, selective serotonin reuptake inhibitor antidepressants) were tried with some success. Here five cases with lichen simplex chronicus and four cases with prurigo nodularis, who responded well to gabapentin, are presented. © 2010 Wiley Periodicals, Inc.
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Adolescent , Adult , Aged , Amines , Analgesics , Anticonvulsants , Cyclohexanecarboxylic Acids , Female , gamma-Aminobutyric Acid , Humans , Male , Middle Aged , Neurodermatitis , Prurigo , Treatment Outcome , Young Adult , antidepressant agent , antihistaminic agent , corticosteroid , gabapentin , adult , aged , article , clinical article , clinical observation , controlled study , disease duration , drug dose increase , drug dose reduction , drug effect , female , follow up , human , male , medical history , neurodermatitis , phototherapy , prurigo nodularis , pruritus , sedation , side effect , skin disease , treatment duration , unspecified side effect