Aspartate-aminotransferase to platelet ratio index score for predicting HELLP syndrome

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dc.contributor.authorŞaşmaz M.İ.
dc.contributor.authorAyvaz M.A.
dc.contributor.authorDülger A.C.
dc.contributor.authorKuday Kaykısız E.K.
dc.contributor.authorGüven R.
dc.date.accessioned2024-07-22T08:07:42Z
dc.date.available2024-07-22T08:07:42Z
dc.date.issued2020
dc.description.abstractIntroduction: HELLP (hemolysis, elevated liver enzyme levels, low platelet counts)-syndrome is a rare but dramatic pregnancy-related illness. The difficult part of this syndrome is the lack of standardised diagnostic criterias and tests to be used to predict it. The aim of this study is determining the role of APRI score in the diagnosis of HELLP syndrome. Material and methods: In this cross sectional, retrospective study, patients with HELLP syndrome as case group and age-matched healthy pregnants at the similar pregnancy trimester as control group were included between January 12,017 and May 31, 2018. Data including sex, age, laboratory values, prognosis were recorded from the computerized system of the hospital. The p-value <0.05 was considered statistically significant. Results: 40 patients with HELLP syndrome and 124 age-matched healthy pregnants included in the study. There was a statistically significant difference between control group and HELLP patients in terms of the mean urinary protein, platelet count, ALT, AST, creatinin, D dimer levels and also the mean APRI score. In the multivariate regression analysis, APRI score was found a better predictor than AST and both were in a good significant in predicting HELLP. On the ROC curve in order to distinguish the patients with HELLP from the control group for AST and APRI score, the sensitivity was found to be 71.7% and 82.6%, specificity to be 91.2% and 87.6% respectively. Maternal mortality rate of HELLP syndrome was 10%. Conclusion: We concluded that the APRI score was robustly predicted HELLP syndrome than AST alone in this study. Further studies are needed to support our data with prospective, multicentre, larger patient groups. © 2019 Elsevier Inc.
dc.identifier.DOI-ID10.1016/j.ajem.2019.02.014
dc.identifier.issn07356757
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/14067
dc.language.isoEnglish
dc.publisherW.B. Saunders
dc.subjectAdult
dc.subjectAspartate Aminotransferases
dc.subjectBiomarkers
dc.subjectCase-Control Studies
dc.subjectCross-Sectional Studies
dc.subjectFemale
dc.subjectHELLP Syndrome
dc.subjectHumans
dc.subjectPlatelet Count
dc.subjectPredictive Value of Tests
dc.subjectPregnancy
dc.subjectProteinuria
dc.subjectReference Standards
dc.subjectRetrospective Studies
dc.subjectalanine aminotransferase
dc.subjectaspartate aminotransferase
dc.subjectcreatinine
dc.subjectD dimer
dc.subjectaspartate aminotransferase
dc.subjectbiological marker
dc.subjectadult
dc.subjectArticle
dc.subjectaspartate aminotransferase to platelet ratio index
dc.subjectclinical article
dc.subjectcontrolled study
dc.subjectcross-sectional study
dc.subjectdiagnostic test accuracy study
dc.subjectfemale
dc.subjectHELLP syndrome
dc.subjecthematological parameters
dc.subjecthuman
dc.subjectmaternal mortality
dc.subjectplatelet count
dc.subjectprediction
dc.subjectpregnancy
dc.subjectpriority journal
dc.subjectprotein urine level
dc.subjectreceiver operating characteristic
dc.subjectretrospective study
dc.subjectsensitivity and specificity
dc.subjectblood
dc.subjectcase control study
dc.subjectHELLP syndrome
dc.subjectmortality
dc.subjectpredictive value
dc.subjectproteinuria
dc.subjectstandard
dc.titleAspartate-aminotransferase to platelet ratio index score for predicting HELLP syndrome
dc.typeArticle

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