Pulmonary hypertension in patients with chronic renal failure

Simple item page
dc.contributor.authorHavlucu Y.
dc.contributor.authorKursat S.
dc.contributor.authorEkmekci C.
dc.contributor.authorCelik P.
dc.contributor.authorSerter S.
dc.contributor.authorBayturan O.
dc.contributor.authorDinc G.
dc.date.accessioned2024-07-22T08:22:44Z
dc.date.available2024-07-22T08:22:44Z
dc.date.issued2007
dc.description.abstractBackground: Many etiologies causing pulmonary hypertension (PH) have been reported, and one of the background disease seen with patients with PH is chronic renal failure (CRF); however, the pathogenesis of PH in this group of patients is not explained satisfactorily. Objectives: The aims of this study were to evaluate the incidence of unexplained PH among patients with CRF and to suggest possible etiologic factors. Methods: Two hundred and eleven patients with CRF were evaluated and the ones who have comorbid conditions that cause PH were excluded. Pulmonary arterial pressure (PAP) and cardiac functions were evaluated by Doppler echocardiography. Arteriovenous fistula (AVF) flow was measured by Doppler sonography. The patients were followed for at least 6 months. Results: Forty-eight CRF patients (20 males, 28 females) were included: 23 were predialysis patients, and 25 patients received hemodialysis via AVF. Patients were followed for 7.5 ± 1.01 months. Systolic PAP >35 mm Hg was found in 56% (14/25) of patients receiving hemodialysis (36.8 ± 10.7 mm Hg) and in 39.1% (9/23) of predialysis patients (29.5 ± 9.5 mm Hg). The parathyroid hormone level, cardiac output values and CRF duration were found to be increased in patients with elevated systolic PAP (p < 0.05). AVF flow and AVF duration were positively correlated with systolic PAP in patients receiving hemodialysis (p < 0.05). There was a negative correlation between systolic PAP and residual urine volume (p < 0.05). AVF compression in hemodialysis patients decreased systolic PAP from 36.8 ± 10.7 to 32.8 ± 10.5 mm Hg. Systolic PAP values were increased at the end of the study in the predialysis group, whereas they were decreased at the end of the follow-up in the hemodialysis group (36.9 ± 10.5 and 32.04 ± 10.5 mm Hg, respectively). Conclusions: This study demonstrates a high incidence of PH among patients with CRF. CRF duration, AVF flow, parathyroid hormone level and cardiac output may be involved in the pathogenesis of PH. The effective hemodialysis and dry weight reduction decreased systolic PAP values. Copyright © 2007 S. Karger AG.
dc.identifier.DOI-ID10.1159/000102953
dc.identifier.issn00257931
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/19218
dc.language.isoEnglish
dc.subjectAdult
dc.subjectAged
dc.subjectAged, 80 and over
dc.subjectCardiac Output
dc.subjectEchocardiography, Doppler
dc.subjectFemale
dc.subjectHumans
dc.subjectHypertension, Pulmonary
dc.subjectKidney Failure, Chronic
dc.subjectMale
dc.subjectMiddle Aged
dc.subjectParathyroid Hormone
dc.subjectRenal Dialysis
dc.subjectTime Factors
dc.subjectadult
dc.subjectaged
dc.subjectarteriovenous fistula
dc.subjectarticle
dc.subjectchronic kidney failure
dc.subjectclinical article
dc.subjectcontrolled study
dc.subjectdisease duration
dc.subjectDoppler echocardiography
dc.subjectfemale
dc.subjectfollow up
dc.subjectheart function
dc.subjectheart output
dc.subjecthemodialysis
dc.subjecthuman
dc.subjectlung artery pressure
dc.subjectmale
dc.subjectmorbidity
dc.subjectpathogenesis
dc.subjectpriority journal
dc.subjectpulmonary hypertension
dc.titlePulmonary hypertension in patients with chronic renal failure
dc.typeArticle

Files

Collections

Scopus Koleksiyonu