The effect of lipoic acid on wound healing in a full thickness uterine injury model in rats

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dc.contributor.authorMicili, SC
dc.contributor.authorGoker, A
dc.contributor.authorSayin, O
dc.contributor.authorAkokay, P
dc.contributor.authorErgur, BU
dc.date.accessioned2025-04-10T10:32:44Z
dc.date.available2025-04-10T10:32:44Z
dc.description.abstractAim of this study was to investigate the effects of lipoic acid on uterine wound healing by immunohistochemical and biochemical assay in a rat uterine horn model with full thickness injury. Thirty-two female Wistar albino rats were randomised into five groups: Control group, with no intervention; uterine scar group 15days (US15d), uterine scar group 15 days + alpha lipoic acid (ALA) (US15d + ALA), uterine scar group 30 days (US30d) and uterine scar group 30 days + ALA (US30 days + ALA). After uterine incision 100 mg/kg of ALA was administered by oral gavage for either 15 or 30 days. Vascular endothelial growth factor (VEGF) and alpha smooth muscle actin (alpha-SMA) distribution were evaluated by immunohistochemical methods in tissue and ELISA methods in tissue homogenate. The percentage of alpha-SMA positive area in US15d + ALA and US30d + ALA groups was significantly higher than US15 and US30d groups. The percentage of VEGF positive area in US15d + ALA group was significantly higher than US15d group and US30d + ALA group was significantly higher than US30d group. Biochemically, alpha-SMA was significantly higher in the US15d + ALA group when compared to US15d group and higher in US30d + ALA group when compared to US30d group. VEGF was significantly higher in US15d + ALA and US30d + ALA groups when compared to US15 and US30d groups. In conclusion, ALA was found to be effective in enhancing wound healing in uterine full thickness injury.
dc.identifier.e-issn1567-2387
dc.identifier.issn1567-2379
dc.identifier.urihttp://hdl.handle.net/20.500.14701/39082
dc.language.isoEnglish
dc.titleThe effect of lipoic acid on wound healing in a full thickness uterine injury model in rats
dc.typeArticle

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