In vitro assessment of degradation and bioactivity of robocast bioactive glass scaffolds in simulated body fluid
| dc.contributor.author | Deliormanli, AM | |
| dc.date.accessioned | 2025-04-10T10:32:52Z | |
| dc.date.available | 2025-04-10T10:32:52Z | |
| dc.description.abstract | In this study porous three-dimensional scaffolds of borate (13-93B3) bioactive glass were prepared by robocasting and in vitro degradation and bioactivity was evaluated. Grid like scaffolds with interconnected pores was assembled using robotic deposition technique which is a direct ink writing method. After binder burnout, the constructs were sintered for 1 h at 560 degrees C to produce scaffolds (porosity approximate to 60%) consisting of dense glass struts (300 +/- 20 mu m in diameter) and interconnected pores of width 580 +/- 20 mu m. Hydroxyapatite formation on borate bioactive glass scaffolds was investigated in simulated body fluid (SBF) using three different scaffold/SBF (S/S) ratios (1, 2 and 10 mg/ml) at 37 degrees C. When immersed in SBF, degradation rate of the scaffolds and conversion to a calcium phosphate material showed a strong dependence to the S/S ratio. At high solid concentration (10 mg/ml) surface of the glass scaffolds converted to the calcium rich amorphous calcium phosphate after 30 days. At lower solid concentrations (2 and 1 mg/ml) an amorphous calcium phosphate layer formation was observed followed by the conversion to hydroxyapatite. (c) 2012 Elsevier Ltd and Techna Group S.r.l. All rights reserved. | |
| dc.identifier.e-issn | 1873-3956 | |
| dc.identifier.issn | 0272-8842 | |
| dc.identifier.uri | http://hdl.handle.net/20.500.14701/39211 | |
| dc.language.iso | English | |
| dc.title | In vitro assessment of degradation and bioactivity of robocast bioactive glass scaffolds in simulated body fluid | |
| dc.type | Article |