In vivo tissue response and durability of five novel synthetic polymers in a rabbit model; [Biocompatibilità e durata in vivo di cinque nuovi polimeri sintetici testati su coniglio]

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dc.contributor.authorSahin E.
dc.contributor.authorCingi C.
dc.contributor.authorEskiizmir G.
dc.contributor.authorAltintoprak N.
dc.contributor.authorCalli A.
dc.contributor.authorCalli C.
dc.contributor.authorYilgör I.
dc.contributor.authorYilgör E.
dc.date.accessioned2024-07-22T08:11:51Z
dc.date.available2024-07-22T08:11:51Z
dc.date.issued2016
dc.description.abstractAlloplastic materials are frequently used in facial plastic surgeries such as rhinoplasty and nasal reconstruction. Unfortunately, the ideal alloplastic material has not been found. This experimental study evaluates the tissue response and durability of five novel polymers developed as an alloplastic material. In this experimental study involving a tertiary university hospital, six subcuticular pockets were formed at the back of 10 rabbits for the implantation of each polymer and sham group. Each pocket was excised with its adjacent tissue after three months, and collected for histopathological examination. Semi-quantitative examination including neovascularisation, inflammation, fibrosis, abscess formation, multinucleated foreign body giant cells was performed, and integrity of polymer was evaluated. A statistical comparison was performed. No statically significant difference was detected in neovascularisation, inflammation, fibrosis, abscess formation and multinucleated foreign body giant cells when a paired comparison between sham and polymer II, III and IV groups was performed individually. Nevertheless, the degree of fibrosis was less than sham group in polymer I (p =. 027) and V (p =. 018), although the other variables were almost similar. The integrity of polymers III (9 intact, 1 fragmented) and IV (8 intact, 2 absent) was better than the other polymers. These novel synthetic polymers could be considered as good candidates for clinical applicability. All polymers provided satisfactory results in terms of tissue response; however, fibrovascular integration was higher in polymers II, III and IV. In addition, the durability of polymer III and IV was better than the others. © 2016, Pacini Editore S.p.A. All rights reserved.
dc.identifier.DOI-ID10.14639/0392-100X-965
dc.identifier.issn0392100X
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/15799
dc.language.isoEnglish
dc.publisherPacini Editore S.p.A.
dc.rightsAll Open Access; Bronze Open Access; Green Open Access
dc.subjectAnimals
dc.subjectBiocompatible Materials
dc.subjectMaterials Testing
dc.subjectModels, Animal
dc.subjectPolymers
dc.subjectRabbits
dc.subjectRhinoplasty
dc.subjectTime Factors
dc.subjectbiomaterial
dc.subjectpolymer
dc.subjectanimal
dc.subjectanimal model
dc.subjectevaluation study
dc.subjectLeporidae
dc.subjectmaterials testing
dc.subjectnose reconstruction
dc.subjecttime factor
dc.titleIn vivo tissue response and durability of five novel synthetic polymers in a rabbit model; [Biocompatibilità e durata in vivo di cinque nuovi polimeri sintetici testati su coniglio]
dc.typeArticle

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