Leptin expression in proliferative, secretory and hyperplastic endometrial tissues; [Proliferatif, sekretuar ve hiperplazik endometrial dokuda leptin ekspresyonu]

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dc.contributor.authorÖzler A.
dc.contributor.authorKuşçu N.K.
dc.contributor.authorTemiz P.
dc.contributor.authorKandiloǧlu A.R.
dc.contributor.authorKoyuncu F.M.
dc.date.accessioned2024-07-22T08:19:57Z
dc.date.available2024-07-22T08:19:57Z
dc.date.issued2011
dc.description.abstractObjective: The goal of this study was to detect endometrial leptin expression in proliferative and secretory phases and then to compare the results with that of hyperplastic endometrium. Material and Methods: Seventeen proliferative, 23 secretory phase and 18 hyperplastic endometrial tissues diagnosed in our hospital between 2002 and 2007 were included in the study. These samples were stained with leptin antibody using an immunohistochemical method. Endometrial glandular and surface epithelium and stroma were evaluated for staining distribution and intensity. Conclusion: Staining intensity seen in early proliferative phase samples (2.33±0.51) increased significantly throughout the middle (2.40±0.54) and late phases (2.83±0.40) (p<0.05). Early secretory phase samples had the least staining intensity (1.42±0.53), while it increased significantly in later periods (2.38±0.51) (p<0.05). There was no difference in staining intensity among proliferative, secretory and hyperplastic tissues (p>0.05). Conclusion: Although endometrial leptin expression was observed in a differential manner throughout the whole menstrual period, no difference was seen in endometrial hyperplasia. We consider that leptin does not play a role in hyperplastic transformation of the endometrium. © 2011 by the Turkish-German Gynecological Education and Research Foundation.
dc.identifier.DOI-ID10.5152/jtgga.2011.37
dc.identifier.issn13090380
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/17926
dc.language.isoEnglish
dc.rightsAll Open Access; Gold Open Access
dc.subjectleptin
dc.subjectleptin antibody
dc.subjectprotein antibody
dc.subjectunclassified drug
dc.subjectadult
dc.subjectaged
dc.subjectarticle
dc.subjectclinical article
dc.subjectcontrolled study
dc.subjectendometrium hyperplasia
dc.subjectepithelium
dc.subjectfemale
dc.subjecthuman
dc.subjecthuman tissue
dc.subjectimmunohistochemistry
dc.subjectmenstrual cycle
dc.subjectpathogenesis
dc.subjectproliferative phase endometrium
dc.subjectprotein analysis
dc.subjectprotein expression
dc.subjectprotein function
dc.subjectsecretory phase endometrium
dc.subjectstroma
dc.titleLeptin expression in proliferative, secretory and hyperplastic endometrial tissues; [Proliferatif, sekretuar ve hiperplazik endometrial dokuda leptin ekspresyonu]
dc.typeArticle

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