Ondansetron, granisetron, and dexamethasone compared for the prevention of postoperative nausea and vomiting in patients undergoing laparoscopic cholecystectomy: A randomized placebo-controlled study

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dc.contributor.authorErhan Y.
dc.contributor.authorErhan E.
dc.contributor.authorAydede H.
dc.contributor.authorYumus O.
dc.contributor.authorYentur A.
dc.date.accessioned2024-07-22T08:22:17Z
dc.date.available2024-07-22T08:22:17Z
dc.date.issued2008
dc.description.abstractBackground: Laparoscopic cholecystectomies are associated with an appreciably high rate of postoperative nausea and vomiting (PONV). This study was designed to compare the effectiveness of ondansetron, granisetron, and dexamethasone for the prevention of PONV in patients after laparoscopic cholecystectomy. Methods: A total of 80 American Society of Anesthesiologists (ASA) physical class I-II patients scheduled for laparoscopic cholecystectomy were included in this randomized, double blind, placebo-controlled study. All patients received a similar standardized anesthesia and operative treatment. Patients were randomly divided into four groups (n = 20 each). Group 1, consisting of control patients, received 0.9% NaCl; group 2 patients received ondansetron 4 mg i.v.; group 3 patients received granisetron 3 mg i.v.; and group 4 patients received dexamethasone 8 mg i.v., all before the induction of anesthesia. Both nausea and vomiting were assessed during the first 24 h after the procedure. Results: The total incidence of PONV was 75% with placebo, 35% with ondansetron, 30% with granisetron, and 25% with dexamethasone. The incidence of PONV was significantly less frequent in groups receiving antiemetics (p < 0.05). The differences between dexamethasone, granisetron, and ondansetron were not significant. Conclusions: Prophylactic dexamethasone 8 mg i.v. significantly reduced the incidence of PONV in patients undergoing laparoscopic cholecystectomy. Dexamethasone 8 mg was as effective as ondansetron 4 mg and granisetron 3 mg, and it was more effective than placebo. © 2007 Springer Science+Business Media, LLC.
dc.identifier.DOI-ID10.1007/s00464-007-9656-3
dc.identifier.issn14322218
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/19014
dc.language.isoEnglish
dc.subjectAdult
dc.subjectAged
dc.subjectAntiemetics
dc.subjectCholecystectomy, Laparoscopic
dc.subjectDexamethasone
dc.subjectDose-Response Relationship, Drug
dc.subjectDouble-Blind Method
dc.subjectFemale
dc.subjectFollow-Up Studies
dc.subjectGallbladder Diseases
dc.subjectGranisetron
dc.subjectHumans
dc.subjectIncidence
dc.subjectInjections, Intravenous
dc.subjectMale
dc.subjectMiddle Aged
dc.subjectOndansetron
dc.subjectPostoperative Nausea and Vomiting
dc.subjectPreoperative Care
dc.subjectTreatment Outcome
dc.subjectUnited States
dc.subjectdexamethasone
dc.subjectgranisetron
dc.subjectondansetron
dc.subjectplacebo
dc.subjectsodium chloride
dc.subjectabsence of side effects
dc.subjectadult
dc.subjectaged
dc.subjectanesthesia
dc.subjectarticle
dc.subjectcholecystectomy
dc.subjectcomparative study
dc.subjectcontrol group
dc.subjectcontrolled study
dc.subjectdrug efficacy
dc.subjectfemale
dc.subjecthuman
dc.subjectincidence
dc.subjectmajor clinical study
dc.subjectmale
dc.subjectmonotherapy
dc.subjectpostoperative nausea
dc.subjectpriority journal
dc.subjectstatistical significance
dc.subjectvomiting
dc.titleOndansetron, granisetron, and dexamethasone compared for the prevention of postoperative nausea and vomiting in patients undergoing laparoscopic cholecystectomy: A randomized placebo-controlled study
dc.typeArticle

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