The acute effect of orlistat on endothelial function in young obese women

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dc.contributor.authorSekuri C.
dc.contributor.authorTavli T.
dc.contributor.authorAvsar A.
dc.contributor.authorSozcuer H.
dc.contributor.authorUyanik B.S.
dc.contributor.authorAri Z.
dc.date.accessioned2024-07-22T08:24:48Z
dc.date.available2024-07-22T08:24:48Z
dc.date.issued2003
dc.description.abstractRecent studies indicate that abdominal fat accumulation is related to impaired endothelial function in young healthy volunteers. The aim of this study was to determine the acute effect of gastrointestinal lipase inhibitor on brachial flow-mediated vasodilatation and hemodynamic parameters in young obese women. The study population was composed of 42 female obese patients (mean age 29 ± 4 years, age range between 18 and 34 years). Flow-mediated endothelial-dependent vasodilatation was assessed in the brachial artery in response to reactive hyperemia using high-resolution ultrasound. Brachial artery diameter (3.46 ± 0.72 mm to 3.82 ± 0.84 mm) and flow-mediated vasodilation (7.6 ± 0.8% to 9.8 ± 1.6%) changed significantly after 12 weeks of therapy (p < 0.001). Brachial artery flow was not changed (124 ± 92 ml/min to 148 ± 14 ml/min, p > 0.05). The results of this study demonstrate that orlistat improved endothelial function, weight, body mass index and systolic and diastolic blood pressure in young women.
dc.identifier.issn02511649
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/20138
dc.language.isoEnglish
dc.subjectAdult
dc.subjectAnti-Obesity Agents
dc.subjectBlood Pressure
dc.subjectBody Mass Index
dc.subjectBrachial Artery
dc.subjectCholesterol
dc.subjectEndothelium, Vascular
dc.subjectFemale
dc.subjectHeart Rate
dc.subjectHumans
dc.subjectLactones
dc.subjectObesity
dc.subjectTriglycerides
dc.subjectVasodilation
dc.subjecthemoglobin A1c
dc.subjecthigh density lipoprotein cholesterol
dc.subjectlow density lipoprotein cholesterol
dc.subjecttetrahydrolipstatin
dc.subjecttriacylglycerol
dc.subjectadult
dc.subjectarticle
dc.subjectbody mass
dc.subjectbrachial artery
dc.subjectclinical article
dc.subjectclinical trial
dc.subjectcontrolled clinical trial
dc.subjectcontrolled study
dc.subjectdiastolic blood pressure
dc.subjectdrug efficacy
dc.subjectfemale
dc.subjecthuman
dc.subjecthyperemia
dc.subjectobesity
dc.subjectsystolic blood pressure
dc.subjectvascular endothelium
dc.subjectvasodilatation
dc.titleThe acute effect of orlistat on endothelial function in young obese women
dc.typeArticle

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