Atorvastatin treatment decreases inflammatory and proteolytic activity in patients with hypercholesterolemia

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dc.contributor.authorErcan E.
dc.contributor.authorTengiz I.
dc.contributor.authorAltuglu I.
dc.contributor.authorSekuri C.
dc.contributor.authorAliyev E.
dc.contributor.authorErcan H.E.
dc.contributor.authorAkin M.
dc.date.accessioned2024-07-22T08:24:38Z
dc.date.available2024-07-22T08:24:38Z
dc.date.issued2004
dc.description.abstractBackground. Statins have anti-inflammatory and anti-platelet effects, which are known as non-lipid effects. Statin treatment can decrease endogenous inflammatory response. Aim. To study the effects of atorvastatin on matrix metalloproteinase-9 (MMP-9) and high sensitive C-reactive protein (hs-CRP) - markers of the proteinolytic and inflammatory activity. Methods. In this prospective study 44 patients with hypercholesterolemia were randomly assigned into 2 groups; Group 1 (n=22) treated with atorvastatin and diet for 2 months, and Group 2 (n=22) - diet alone. MMP-9 and hs-CRP were measured at baseline and two months later. Results. Groups were matched for age, sex and baseline characteristics. Lipid levels decreased by 32% (LDL from 153.9±26.6 to 94.5±20.8 mg/dl, p<0.005) in the atorvastatin group and by 9% in the diet alone group. Atorvastatin lowered plasma CRP from 5.16±1.9 to 2.88±1.06 mg/L (p<0.001) and MMP-9 activity from 64.3±28.1 to 35.4±20.0 ng/ml (p<0.0001). Atorvastatin-induced reductions in CRP and MMP-9 were greater than in the diet alone group. MMP-9 levels did not show significant changes in Group 2 after two months of diet. Conclusions. Atorvastatin treatment decreases inflammatory and proteolytic activity in patients with hypercholesterolemia.
dc.identifier.issn00229032
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/20068
dc.language.isoEnglish
dc.publisherKlinika Kardiologii CMKP
dc.subjectatorvastatin
dc.subjectC reactive protein
dc.subjectgelatinase B
dc.subjectlow density lipoprotein
dc.subjectstatine derivative
dc.subjectadult
dc.subjectantiinflammatory activity
dc.subjectantiplatelet activity
dc.subjectarticle
dc.subjectclinical article
dc.subjectclinical trial
dc.subjectcontrolled clinical trial
dc.subjectcontrolled study
dc.subjectdiet therapy
dc.subjectdrug activity
dc.subjectdrug effect
dc.subjectenzyme activity
dc.subjectfemale
dc.subjecthuman
dc.subjecthypercholesterolemia
dc.subjectinflammation
dc.subjectintermethod comparison
dc.subjectmale
dc.subjectprospective study
dc.subjectprotein degradation
dc.subjectrandomized controlled trial
dc.titleAtorvastatin treatment decreases inflammatory and proteolytic activity in patients with hypercholesterolemia
dc.typeArticle

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