Effects of trauma and infection on ciprofloxacin levels in the vitreous cavity

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dc.contributor.authorÖztürk F.
dc.contributor.authorKortunay S.
dc.contributor.authorKurt E.
dc.contributor.authorIlker S.S.
dc.contributor.authorInan U.U.
dc.contributor.authorBasci N.E.
dc.contributor.authorBozkurt A.
dc.contributor.authorKayaalp S.O.
dc.date.accessioned2024-07-22T08:25:51Z
dc.date.available2024-07-22T08:25:51Z
dc.date.issued1999
dc.description.abstractObjective: This study was designed to determine the effects of trauma and infection on vitreous ciprofloxacin levels after intravitreal injection of ciprofloxacin in rabbits. Methods: A penetrating injury was made in the right eyes of 24 rabbits. In the eyes of half of the traumatized animals, a standardized intraocular infection was induced by intravitreal injection of a suspension of Staphylococcus aureus. The intact left eyes of the traumatized group were maintained as controls. Ciprofloxacin (200 μg/0.1 mL) was injected into the midvitreous cavity of both eyes in all animals and samples were obtained at 2, 8, 24, and 48 hours after injection. Drug concentrations were measured using high-pressure liquid chromatography analysis. Results: At the second hour, the mean vitreous concentration of ciprofloxacin in the traumatized eyes was lower than that in control eyes (P < 0.05). The mean ciprofloxacin concentrations were significantly higher (P < 0.05) in the traumatized-infected eyes than were those in control or traumatized eyes at 24 and 48 hours. The elimination half-life of ciprofloxacin in control and traumatized eyes was 6.02 hours and 5.02 hours, respectively, and infection prolonged the half-life to 15.06 hours. Vitreous levels of ciprofloxacin were above the minimum inhibitory concentration (MIC90) for most of the common microorganisms causing endophthalmitis in all groups at 2 and 8 hours, but also at 24 and 48 hours in traumatized-infected eyes. Conclusion: Infection appears to decrease the clearance of ciprofloxacin. Therapeutic drug levels in traumatized-infected eyes were maintained up to 48 hours. Assuming that the animal model used may have a predictive value for the drug elimination in traumatized-infected human eyes, we suggest that local administration of ciprofloxacin every 2 days may be relevant from the therapeutic perspective.
dc.identifier.DOI-ID10.1097/00006982-199902000-00007
dc.identifier.issn0275004X
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/20630
dc.language.isoEnglish
dc.publisherLippincott Williams and Wilkins
dc.subjectciprofloxacin
dc.subjectanimal experiment
dc.subjectanimal model
dc.subjectantibiotic therapy
dc.subjectarticle
dc.subjectcontrolled study
dc.subjectdrug distribution
dc.subjectdrug half life
dc.subjectdrug tissue level
dc.subjecteye infection
dc.subjecteye injury
dc.subjectnonhuman
dc.subjectrabbit
dc.subjectStaphylococcus aureus
dc.subjectvitreous disease
dc.titleEffects of trauma and infection on ciprofloxacin levels in the vitreous cavity
dc.typeArticle

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