Effect of selective gut decontamination on peritoneal fibrinolytic activity in rats; [Ratlarda oluşturulan selektif baḡirsak dekontaminasyonunun peritoneal fibrinolitik aktivite üzerine etkisi]

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dc.contributor.authorIlkgül Ö.
dc.contributor.authorErhan Y.
dc.contributor.authorAydede H.
dc.contributor.authorVar A.
dc.contributor.authorOnur E.
dc.date.accessioned2024-07-22T08:24:05Z
dc.date.available2024-07-22T08:24:05Z
dc.date.issued2005
dc.description.abstractPurpose: Our goal with this experiment was to determine the influence of selective decontamination of the digestive tract (SDD) on peritoneal fibrinolytic activity in rats. Materials and Methods: Animals were divided into five groups. Group 1 was subjected to SDD-treated peritoneal adhesion. Group 2 was subjected only to perioneal adhesion. Group 3 was SDD-treated, whereas Group 4 was labeled as the control group. Group 5 was subjected to simple laparotomy. The rats in Group 1 and Group 3 were given SOD (tobramycin 20 mg/l and polymyxin E 25 mg/l) by gavage twice daily for 3 days preceding surgical operation. Control groups were fed orally with standard chow. After a 72-hour waiting period following the operation, biopsies of undamaged parietal peritoneum were obtained from the fibrinolytic parameters in order to measure tissue-type plasminogen activator (tPA) and plasminogen activator inhibitor type-1 (PAI-1). Results: Average tPA levels were low in both the sdd-treated group and the sdd+adhesion model group, however no statistical significance was elicited. PAI-1 levels were higher in sdd-treated groups than in other groups, but no significantly meaningful difference was obtained. Conclusion: These results suggest that pretreatment with sdd reduces the peritoneal fibrinolytic activity and might also enhance the peritoneal adhesion formation in rats.
dc.identifier.issn13000705
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/19820
dc.language.isoTurkish
dc.publisherTurkish Surgical Society
dc.subjectcolistin
dc.subjectplasminogen activator inhibitor 1
dc.subjecttissue plasminogen activator
dc.subjecttobramycin
dc.subjectanimal experiment
dc.subjectanimal model
dc.subjectarticle
dc.subjectcontamination
dc.subjectcontrolled study
dc.subjectfeeding
dc.subjectfibrinolysis
dc.subjectintestine
dc.subjectintestine biopsy
dc.subjectintestine surgery
dc.subjectlaparotomy
dc.subjectnonhuman
dc.subjectparameter
dc.subjectperitoneum adhesion
dc.subjectrat
dc.titleEffect of selective gut decontamination on peritoneal fibrinolytic activity in rats; [Ratlarda oluşturulan selektif baḡirsak dekontaminasyonunun peritoneal fibrinolitik aktivite üzerine etkisi]
dc.typeArticle

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