Neurocognitive effects and electrophysiological findings in ADHD and self-limiting centrotemporal spike wave epilepsy (SeLECTS) − A prospective tertiary care study

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dc.contributor.authorOrak S.A.
dc.contributor.authorBilaç Ö.
dc.contributor.authorPolat M.
dc.contributor.authorSobay N.S.
dc.contributor.authorYalçin A.H.
dc.contributor.authorKorkmaz R.
dc.contributor.authorKubur Ç.Ç.
dc.contributor.authorAtasever A.K.
dc.contributor.authorYilmaz C.
dc.contributor.authorÖzyurt B.C.
dc.date.accessioned2024-07-22T08:01:10Z
dc.date.available2024-07-22T08:01:10Z
dc.date.issued2024
dc.description.abstractObjective: The study aimed to determine the prevalence of attention deficit hyperactivity disorder (ADHD) in patients with self-limiting epilepsy with centrotemporal spike wave (SeLECTS), as well as the electroclinical features associated with this comorbid condition and the neurocognitive effects using psychometric tests. Additionally, we analysed the electrophysiological findings and neurocognitive status of patients with ADHD to estimate the prevalence of epilepsy and neurocognitive effects in the ADHD population and evaluate their clinical features. Method: The study included patients diagnosed with SeLECT and ADHD who were matched for age and gender. Electrophysiological tests, psychometric tests, demographic and clinical characteristics of SeLECTS patients aged 7–13 years and ADHD patients of similar age were analysed. The study examined electrophysiological and psychometric tests, as well as demographic and clinical characteristics. Both groups underwent testing using the Wechsler Intelligence Scale for Children (WISC-R), Stroop Colour and Word Test (SCWT), and EEG (Electroencephalogram). The SeLECT group also underwent the Bender Visual-Motor Gestalt Test. Rsults: No significant relationship was found between the SeLECT and ADHD groups in terms of age and gender. The rate of epileptiform discharge in EEG findings without a diagnosis of epilepsy was 5.6 % (n = 2) in the ADHD group. The rate of ADHD in the SeLECTS group was 28 % (n = 11). Although all subsections of the WISCR test were higher in the ADHD patient group than in the SeLECTS patient group, only verbal IQ and total IQ showed a significant difference. No significant differences were found between the completion times, error rates, and correction averages of the SCWT sections in both groups. There was no significant correlation found between the performance IQ, verbal IQ, and total intelligence scores in either the isolated SeLECTS patient group or the SeLECTS + ADHD patient group (p > 0.05). However, it is worth noting that verbal IQ was below normal in both groups and slightly lower in the SeLECT + ADHD group. Additionally, the mean SeWT completion time was significantly longer in the SeLECT + ADHD group than in the isolated SeLECT group. However, no significant difference was found in the Bender Gestalt Visual Motor Perception Test. In the psychometric analyses comparing the isolated SeLECTS, SeLECT + ADHD, and ADHD patient groups, the SCWT completion times were significantly longer in the SeLECT + ADHD group than in the other two groups. The verbal IQ score was significantly higher in the ADHD group than in the other two groups. Conclusion: In conclusion, although SeLECTS is commonly considered a benign form of epilepsy, our study found a high rate of comorbidity with ADHD. This condition has a negative impact on verbal intelligence and sustained attention, highlighting the importance of a complete neuropsychological evaluation at the stage of epilepsy diagnosis. It is crucial not to overlook the possibility of an ADHD diagnosis. © 2024
dc.identifier.DOI-ID10.1016/j.yebeh.2024.109900
dc.identifier.issn15255050
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/11354
dc.language.isoEnglish
dc.publisherAcademic Press Inc.
dc.subjectanticonvulsive agent
dc.subjectArticle
dc.subjectattention deficit hyperactivity disorder
dc.subjectBender Gestalt test
dc.subjectchild
dc.subjectchildhood epilepsy
dc.subjectcognition
dc.subjectcomorbidity
dc.subjectcross-sectional study
dc.subjectelectroencephalography
dc.subjectelectrophysiology
dc.subjectfemale
dc.subjecthuman
dc.subjecthyperventilation
dc.subjectintelligence
dc.subjectintelligence quotient
dc.subjectKruskal Wallis test
dc.subjectmajor clinical study
dc.subjectmale
dc.subjectneuropsychological assessment
dc.subjectprevalence
dc.subjectprospective study
dc.subjectpsychometry
dc.subjectreliability
dc.subjectSchedule for Affective Disorders and Schizophrenia
dc.subjectschool child
dc.subjectself limiting centrotemporal spike wave epilepsy
dc.subjectsemi structured interview
dc.subjectspike wave
dc.subjectStroop test
dc.subjectvisuomotor coordination
dc.subjectwakefulness
dc.subjectWechsler intelligence scale for children
dc.titleNeurocognitive effects and electrophysiological findings in ADHD and self-limiting centrotemporal spike wave epilepsy (SeLECTS) − A prospective tertiary care study
dc.typeArticle

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