Comparison of the effectiveness of caspofungin and liposomal amphotericin-b for the treatment of c. Tropicalis-induced peritonitis in mice

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dc.contributor.authorDemirci M.
dc.contributor.authorTünger Ö.
dc.contributor.authorÇetin Ç.D.B.
dc.contributor.authorSenol S.E.B.
dc.date.accessioned2024-07-22T08:09:13Z
dc.date.available2024-07-22T08:09:13Z
dc.date.issued2019
dc.description.abstractIn order to compare the effectiveness of liposomal amphotericin B (LAB) and caspofungin monotherapy in Candida tropicalis-induced peritonitis in an experimental mice model 56 healthy male BALB/c mice (10-12 weeks; 20-25 g) were divided into groups and C. tropicalis strains were intraperitoneally (IP) inoculated into mice groups except the control group. After the injection, three doses of LAB (0.5, 1.0, 2.0 mg/kg/day) and caspofungin (1.0, 2.0, 5.0 mg/kg/ day) were administered to groups for five consecutive days, starting 48 h post-infection. The mice were then followed up for 14 days and killed by cervical dislocation. When their peritoneal fluid was examined, the difference in fungal growth between the treatment group and control group was significant (p<0.05). Evaluation of the treatment groups revealed that fungal growth decreased with increasing dose of the antifungal agent (p>0.05). There was no dose-related difference from mice which received LAB or those which received caspofungin in our experimental model. During our study, no death was detected despite the similar injection doses compared with other studies using Candida species. The results of this study suggest that C. tropicalis could have lower virulence, perhaps limited by natural immunity, and causes mortality at much higher doses. © 2019, EDIMES Edizioni Medico Scientifiche. All rights reserved.
dc.identifier.issn11249390
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/14736
dc.language.isoEnglish
dc.publisherEDIMES Edizioni Medico Scientifiche
dc.subjectAmphotericin B
dc.subjectAnimals
dc.subjectAntifungal Agents
dc.subjectCandida tropicalis
dc.subjectCandidiasis, Invasive
dc.subjectCaspofungin
dc.subjectMale
dc.subjectMice
dc.subjectMice, Inbred BALB C
dc.subjectPeritonitis
dc.subjectRandom Allocation
dc.subjectamphotericin B lipid complex
dc.subjectcaspofungin
dc.subjectfluconazole
dc.subjectitraconazole
dc.subjectvoriconazole
dc.subjectamphotericin B
dc.subjectamphotericin B lipid complex
dc.subjectantifungal agent
dc.subjectcaspofungin
dc.subjectanimal experiment
dc.subjectanimal model
dc.subjectanimal tissue
dc.subjectArticle
dc.subjectBagg albino mouse
dc.subjectCandida tropicalis
dc.subjectcolony forming unit
dc.subjectcomparative effectiveness
dc.subjectcontrolled study
dc.subjectdrug efficacy
dc.subjectexperimental peritonitis
dc.subjectfungal virulence
dc.subjectfungus growth
dc.subjectinnate immunity
dc.subjectmale
dc.subjectminimum inhibitory concentration
dc.subjectmonotherapy
dc.subjectmouse
dc.subjectnonhuman
dc.subjectperitoneal fluid
dc.subjectanimal
dc.subjectcomparative study
dc.subjectdrug effect
dc.subjectgrowth, development and aging
dc.subjectinvasive candidiasis
dc.subjectmicrobiology
dc.subjectperitonitis
dc.subjectrandomization
dc.titleComparison of the effectiveness of caspofungin and liposomal amphotericin-b for the treatment of c. Tropicalis-induced peritonitis in mice
dc.typeArticle

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