Serum N-terminal-pro-brain natriuretic peptide (NT-pro-BNP) and homocysteine levels in type 2 diabetic patients with asymptomatic left ventricular diastolic dysfunction

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dc.contributor.authorGörmüş U.
dc.contributor.authorÖzmen D.
dc.contributor.authorÖzmen B.
dc.contributor.authorParildar Z.
dc.contributor.authorÖzdoǧan O.
dc.contributor.authorMutaf I.
dc.contributor.authorBayindir O.
dc.date.accessioned2024-07-22T08:21:13Z
dc.date.available2024-07-22T08:21:13Z
dc.date.issued2010
dc.description.abstractAims: : The aim of this study was to determine serum NT-proBNP and plasma Hcy levels and to explore the relationship between serum NT-proBNP and plasma Hcy levels in type 2 diabetic patients with and without asymptomatic LVDD. Methods: : NT-proBNP and Hcy levels were measured 31 patients with type 2 diabetes mellitus. According to echocardiographic data, diabetic patients were divided into two groups: normal LV function or LV diastolic dysfunction. Results: : Serum NT-proBNP levels in diabetic patients with LVDD were significantly higher than in diabetic patients with normal LV function and controls. The area under the receiver-operating characteristic (ROC) curve for NT-proBNP to separate normal vs. diastolic dysfunction was 0.96 in type 2 diabetic patients. Plasma Hcy levels were significantly higher in both diabetic groups than in controls. Positive correlation was noted between NT-proBNP and Hcy levels in diabetic patients with LVDD (r = 0.881, p = 0.0001). Conclusions: : The correlation between elevated NT-proBNP and Hcy levels in diabetic patients with LVDD suggest an association between homocysteinemia and increased NT-proBNP secretion. Our data indicate that NT-proBNP may be a simple screening tool to select diabetic patients with LVDD requiring further examination with echocardiography. © 2009 Elsevier Ireland Ltd. All rights reserved.
dc.identifier.DOI-ID10.1016/j.diabres.2009.10.010
dc.identifier.issn01688227
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/18509
dc.language.isoEnglish
dc.subjectBlood Pressure
dc.subjectCreatinine
dc.subjectDiabetes Mellitus, Type 2
dc.subjectDiabetic Angiopathies
dc.subjectDiastole
dc.subjectEchocardiography
dc.subjectEchocardiography, Transesophageal
dc.subjectFemale
dc.subjectHomocysteine
dc.subjectHumans
dc.subjectMale
dc.subjectMiddle Aged
dc.subjectNatriuretic Peptide, Brain
dc.subjectPeptide Fragments
dc.subjectVentricular Dysfunction, Left
dc.subjectVentricular Function, Left
dc.subjectamino terminal pro brain natriuretic peptide
dc.subjecthomocysteine
dc.subjectarticle
dc.subjectblood analysis
dc.subjectclinical article
dc.subjectcontrolled study
dc.subjectcreatinine blood level
dc.subjectechocardiography
dc.subjectfemale
dc.subjectheart left ventricle failure
dc.subjecthuman
dc.subjecthyperhomocysteinemia
dc.subjectmale
dc.subjectnon insulin dependent diabetes mellitus
dc.subjectscreening test
dc.titleSerum N-terminal-pro-brain natriuretic peptide (NT-pro-BNP) and homocysteine levels in type 2 diabetic patients with asymptomatic left ventricular diastolic dysfunction
dc.typeArticle

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