Senescence-mediated anticancer effects of quercetin

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dc.contributor.authorÖzsoy Gökbilen S.
dc.contributor.authorBecer E.
dc.contributor.authorVatansever H.S.
dc.date.accessioned2024-07-22T08:04:13Z
dc.date.available2024-07-22T08:04:13Z
dc.date.issued2022
dc.description.abstractCellular senescence plays a key role in aging and age-related disease initiation. It is a highly dynamic and multistep process that can be stimulated by various stimuli, including cellular stress, DNA damage, telomere shortening, and oncogene activation. Also, senescence is a potent antitumor mechanism, by preventing the proliferation of cancerous cells. However, some of the senescent cells have apoptosis resistance and can cause recurrence in cancer. A new class of drugs termed senolytics selectively kill and eliminate senescent cells. In recent years, natural compounds such as quercetin have been discovered to be effective as senolytic agents. Quercetin is a phytochemical that has strong antioxidant properties and pro-apoptotic effects and has been investigated for many years. Additionally, it has great potential to be used as a senolytic agent. According to preclinical and early-phase clinical data of senolytic agent research, quercetin administration appears to be effective in preventing or alleviating cancer formation. In this paper, we review the importance of cellular senescence in carcinogenesis and the effects of quercetin on senescence, as well as quercetin's potential effects as a pro-apoptotic agent and suppressor of cancer cell proliferation. © 2022 Elsevier Inc.
dc.identifier.DOI-ID10.1016/j.nutres.2022.04.007
dc.identifier.issn02715317
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/12603
dc.language.isoEnglish
dc.publisherElsevier Inc.
dc.subjectAging
dc.subjectApoptosis
dc.subjectCellular Senescence
dc.subjectHumans
dc.subjectNeoplasms
dc.subjectQuercetin
dc.subjectSenotherapeutics
dc.subjectbleomycin
dc.subjectcyclin A
dc.subjectcyclin B1
dc.subjectcyclin D
dc.subjectcyclin dependent kinase 1
dc.subjectcyclin dependent kinase 2
dc.subjectcyclin dependent kinase 4
dc.subjectcyclin dependent kinase 6
dc.subjectcyclin E
dc.subjectdoxorubicin
dc.subjectperoxisome proliferator activated receptor
dc.subjectprotein p16
dc.subjectprotein p21
dc.subjectprotein p53
dc.subjectquercetin
dc.subjectquercetin
dc.subjectA-549 cell line
dc.subjectantineoplastic activity
dc.subjectcancer cell
dc.subjectcarcinogenesis
dc.subjectcell aging
dc.subjectcell cycle arrest
dc.subjectcell cycle G2 phase
dc.subjectcell cycle M phase
dc.subjectcell proliferation
dc.subjectCOLO 320 cell line
dc.subjectfibroblast
dc.subjectgene mutation
dc.subjectglioma cell line
dc.subjecthuman
dc.subjectmetastasis
dc.subjectosteosarcoma cell line
dc.subjectoxidative stress
dc.subjectReview
dc.subjectSK-OV-3-Luc cell line
dc.subjecttherapy effect
dc.subjecttumor suppressor gene
dc.subjectU-251MG cell line
dc.subjectU2OS cell line
dc.subjectaging
dc.subjectapoptosis
dc.subjectcell aging
dc.subjectneoplasm
dc.subjectphysiology
dc.titleSenescence-mediated anticancer effects of quercetin
dc.typeReview

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