Enhancement of taxane-induced cytotoxicity and apoptosis by gossypol in human breast cancer cell line MCF-7

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dc.contributor.authorKaraca B.
dc.contributor.authorAtmaca H.
dc.contributor.authorUzunoglu S.
dc.contributor.authorKarabulut B.
dc.contributor.authorSanli U.A.
dc.contributor.authorUslu R.
dc.date.accessioned2024-07-22T08:21:25Z
dc.date.available2024-07-22T08:21:25Z
dc.date.issued2009
dc.description.abstractPurpose: Gossypol is a natural polyphenolic compound extracted from cotton plant (Gossypium species) which has shown potent inhibitory effect on cell growth of many types of cancers. In this study, we aimed to evaluate the interaction of gossypol with some conventional drugs known to be effective in the treatment of breast cancer, like taxanes, doxorubicin, gemcitabine, cisplatin and vinorelbine, in MCF-7 breast cancer cells. Materials and methods: The XTT viability assay was used to evaluate the cytotoxicity of various cytotoxic agents alone and in combination with gossypol in MCF-7 breast cancer cells. The combination effect analysis of Chou and Talalay was used to identify the most synergistic drug combinations. The possible synergistic effects of the combination of drugs on apoptosis were also evaluated by using two different apoptosis assays. Results: We identified strong synergistic cytotoxic and apoptotic activity of gossypol with taxanes among all other studied cytotoxic drugs. Conclusion: This study provides proof that gossypol combined with taxanes may have potential as a novel future treatment for breast cancer. © 2009 Zerbinis Medical Publications.
dc.identifier.issn11070625
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/18602
dc.language.isoEnglish
dc.subjectAntineoplastic Agents
dc.subjectApoptosis
dc.subjectBreast Neoplasms
dc.subjectCell Line, Tumor
dc.subjectCell Proliferation
dc.subjectCell Survival
dc.subjectDrug Synergism
dc.subjectFemale
dc.subjectGossypol
dc.subjectHumans
dc.subjectTaxoids
dc.subjectacridine orange
dc.subjectcisplatin
dc.subjectdocetaxel
dc.subjectdoxorubicin
dc.subjectgemcitabine
dc.subjectgossypol
dc.subjectnavelbine
dc.subjectpaclitaxel
dc.subjectantineoplastic activity
dc.subjectapoptosis
dc.subjectarticle
dc.subjectbreast cancer
dc.subjectcancer combination chemotherapy
dc.subjectcell strain MCF 7
dc.subjectcell viability
dc.subjectconcentration response
dc.subjectcontrolled study
dc.subjectcytotoxicity
dc.subjectDNA fragmentation
dc.subjectdrug antagonism
dc.subjectdrug effect
dc.subjectdrug efficacy
dc.subjectdrug potentiation
dc.subjecthuman
dc.subjecthuman cell
dc.titleEnhancement of taxane-induced cytotoxicity and apoptosis by gossypol in human breast cancer cell line MCF-7
dc.typeArticle

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