Increased mean platelet volume in hypertrophic cardiomyopathy

Simple item page
dc.contributor.authorIcli A.
dc.contributor.authorAksoy F.
dc.contributor.authorDogan A.
dc.contributor.authorArslan A.
dc.contributor.authorAkcay S.
dc.contributor.authorYücel H.
dc.contributor.authorErsoy I.
dc.contributor.authorGorgulu O.
dc.date.accessioned2024-07-22T08:17:15Z
dc.date.available2024-07-22T08:17:15Z
dc.date.issued2014
dc.description.abstractThromboembolic events may be seen in patients with hypertrophic cardiomyopathy (HCM). We investigated the mean platelet volume (MPV), an indicator of platelet activation in patients with HCM. This study included 112 patients with HCM, in which 40 were patients with hypertrophic obstructive cardiomyopathy (HOCM), and 106 were control participants. The MPV was significantly higher in patients with HCM than in controls (9.1 ± 0.3 vs 7.9 ± 0.3 fL, P =.01). In the subgroup analyses, MPV was also higher in patients with HOCM compared to those with hypertrophic nonobstructive cardiomyopathy (HNCM; 9.3 ± 0.3 vs 9.0 ± 0.2 fL, P =.01). Similarly, patients with HNCM had higher MPV values than controls (9.0 ± 0.2 vs 7.9 ± 0.3 fL, P =.01). The MPV was significantly and positively correlated with left ventricular outflow tract (LVOT) obstruction (r =.42, P =.001) and septal thickness (r =.62, P =.001). In linear regression analysis, MPV was independently associated only with septal thickness (β =.07, 95% confidence interval: 0.04-0.09, P =.001). The MPV can be elevated in patients with HCM regardless of the obstruction of LVOT and may be associated with the severity of septal thickness. © The Author(s) 2013.
dc.identifier.DOI-ID10.1177/0003319713483919
dc.identifier.issn00033197
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/17001
dc.language.isoEnglish
dc.publisherSAGE Publications Inc.
dc.subjectAdult
dc.subjectCardiomyopathy, Hypertrophic
dc.subjectCase-Control Studies
dc.subjectChi-Square Distribution
dc.subjectFemale
dc.subjectHeart Septum
dc.subjectHumans
dc.subjectLinear Models
dc.subjectMale
dc.subjectMean Platelet Volume
dc.subjectMiddle Aged
dc.subjectMultivariate Analysis
dc.subjectPlatelet Activation
dc.subjectPredictive Value of Tests
dc.subjectRisk Factors
dc.subjectVentricular Outflow Obstruction
dc.subjecthypertrophic cardiomyopathy
dc.subjectmean platelet volume
dc.subjectplatelet activation
dc.subjectadult
dc.subjectarticle
dc.subjectcontrolled study
dc.subjectechocardiography
dc.subjectfemale
dc.subjectheart left ventricle outflow tract
dc.subjectheart left ventricle outflow tract obstruction
dc.subjectheart ventricle septum
dc.subjecthuman
dc.subjecthypertrophic cardiomyopathy
dc.subjecthypertrophic obstructive cardiomyopathy
dc.subjectmajor clinical study
dc.subjectmale
dc.subjectthrombocyte activation
dc.subjectthrombocyte volume
dc.titleIncreased mean platelet volume in hypertrophic cardiomyopathy
dc.typeArticle

Files

Collections

Scopus Koleksiyonu