Renal cell carcinoma: New prognostic factors?

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dc.contributor.authorKirkali Z.
dc.contributor.authorLekili M.
dc.date.accessioned2024-07-22T08:24:46Z
dc.date.available2024-07-22T08:24:46Z
dc.date.issued2003
dc.description.abstractPurpose of review: There are limited independent predictors of survival in patients with renal cell carcinoma. Factors related to the tumor, host and treatment may help us to predict prognosis to a certain extent. Prognostic indicators would enable selection of patients who can benefit from adjuvant therapy and thus should be enrolled in clinical trials. This review highlights developments in the identification of current prognosticators for patients with renal cell carcinoma. Recent findings: Tumor stage, grade and patient-performance status are the known prognostic indicators in renal cell carcinoma. Besides these parameters, many molecular and cytogenetic markers were evaluated recently. Unfortunately, none of these parameters appear to be a better predictive prognostic factor than the usual staging and grading. Therefore, efforts to identify new markers for tumor proliferation and progression are still ongoing. It was recently reported that low carbonic anhydrase 9 staining may be an independent poor prognostic factor in patients with renal cell carcinoma. Moreover, there is increasing interest in prognostic indices and predictive algorithms for survival. Staging systems that combine the pathological features with additional prognostic variables have been constructed to predict outcome. The UCLA Integrated Staging System seems to be superior to staging alone in differentiating patients' survival. Summary: Although the literature reviewed contains numerous promising clinical, histological, molecular and cytogenetic parameters, none of them has yet been shown to have an independent prognostic value.
dc.identifier.DOI-ID10.1097/00042307-200311000-00002
dc.identifier.issn09630643
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/20121
dc.language.isoEnglish
dc.subjectAdult
dc.subjectAge Factors
dc.subjectAged
dc.subjectAlgorithms
dc.subjectCarcinoma, Renal Cell
dc.subjectFemale
dc.subjectGenetic Markers
dc.subjectHumans
dc.subjectKidney Neoplasms
dc.subjectMale
dc.subjectMiddle Aged
dc.subjectNeoplasm Staging
dc.subjectNeovascularization, Pathologic
dc.subjectPrognosis
dc.subjectSex Factors
dc.subjectTumor Markers, Biological
dc.subjectbiological marker
dc.subjectcarbonate dehydratase
dc.subjectcarbonate dehydratase IX
dc.subjectintercellular adhesion molecule 1
dc.subjectinterleukin 12
dc.subjectinterleukin 2 receptor
dc.subjectunclassified drug
dc.subjectvasculotropin
dc.subjectalgorithm
dc.subjectangiogenesis
dc.subjectapoptosis
dc.subjectcancer size
dc.subjectcancer staging
dc.subjectcancer surgery
dc.subjectcancer survival
dc.subjectclinical feature
dc.subjectdisease marker
dc.subjectgender
dc.subjecthistopathology
dc.subjecthuman
dc.subjectimmunotherapy
dc.subjectkidney carcinoma
dc.subjectnephrectomy
dc.subjectoutcomes research
dc.subjectparaneoplastic syndrome
dc.subjectpathology
dc.subjectprediction
dc.subjectprevalence
dc.subjectpriority journal
dc.subjectprognosis
dc.subjectreview
dc.titleRenal cell carcinoma: New prognostic factors?
dc.typeReview

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