Is melatonin protective in contrast material related renal failure?; [Melatonin kontrast madde ile ilişkili renal yetmezlikten korur mu?]

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dc.contributor.authorTuncyurek O.
dc.contributor.authorGunay O.
dc.contributor.authorTaneli F.
dc.contributor.authorAyhan S.
dc.contributor.authorNese N.
dc.contributor.authorPabuscu Y.
dc.date.accessioned2024-07-22T08:14:18Z
dc.date.available2024-07-22T08:14:18Z
dc.date.issued2015
dc.description.abstractAim: The aim of the study was to investigate the effect of melatonin on the renal injury resulting from radiocontrast media and myoglobinuria in male Wistar albino rats. Material and Method: 50% glycerol at equal amounts was intramuscularly administered to both hind legs of all animals under ether anesthesia at the dose of 10 mg/kg. Three hours later, the groups were ad-ministered the following: Group I (number:7): Iopromide(Ultravist -300®) at the dose of 2 ml/kg (intracardiac); Group II (number:7): Iopromide(Ultravist -300®) and intraperitoneally administered Melatonin at the dose of 10 mg/kg (Melatonin was dissolved in 7.5% absolute ethanol and further dilutions were made in saline.); and Group III (number:7): 2 ml/kg of sterile physiologic saline (Control group). The levels of Uurea, Ccreatinine and Ccystatin C were studied on the blood samples collected. The renal samples were evaluated by 2two distinct pathologists who did not know the protocol. Results: There was no difference in the values of Creatinine and cystatin c between Groups 2 and 3 (p=0.9; 0.2). Discussion: In conclusion, we evaluated the possible prevention of contrast-induced oxidative stress in the kidney with using melatonin. How-ever, additional clinical studies are needed to evaluate the role of preventive melatonin treatment in humans. © 2015, Journal of Clinical and Analytical Medicine. All rights reserved.
dc.identifier.DOI-ID10.4328/JCAM.1929
dc.identifier.issn13090720
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/16547
dc.language.isoEnglish
dc.publisherJournal of Clinical and Analytical Medicine
dc.subjectcreatinine
dc.subjectcystatin C
dc.subjectmelatonin
dc.subjecturea
dc.subjectanimal experiment
dc.subjectanimal model
dc.subjectanimal tissue
dc.subjectArticle
dc.subjectblood sampling
dc.subjectcontrast induced nephropathy
dc.subjectcontrolled study
dc.subjectcreatinine blood level
dc.subjectdrug effect
dc.subjectenzyme blood level
dc.subjecthistopathology
dc.subjectmale
dc.subjectmyoglobinuria
dc.subjectnonhuman
dc.subjectoxidative stress
dc.subjectrat
dc.subjectrenal protection
dc.subjecturea blood level
dc.titleIs melatonin protective in contrast material related renal failure?; [Melatonin kontrast madde ile ilişkili renal yetmezlikten korur mu?]
dc.typeArticle

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