Synthesis, radiolabeling and in vivo biodistribution of diethylstilbestrol phosphate derivative (DES-P)

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dc.contributor.authorÜnak P.
dc.contributor.authorBiber Müftüler F.Z.
dc.contributor.authorIçhedef Ç.
dc.contributor.authorMedine E.I.
dc.contributor.authorÖzmen K.
dc.contributor.authorÜnak T.
dc.contributor.authorKilçar A.Y.
dc.contributor.authorGümüşer F.G.
dc.contributor.authorParlak Y.
dc.contributor.authorBilgin E.S.
dc.date.accessioned2024-07-22T08:19:16Z
dc.date.available2024-07-22T08:19:16Z
dc.date.issued2012
dc.description.abstractDiethylstilbestrol (DES) is a well known, nonsteroidal estrogen with high affinity for the estrogen receptor (ER). Today DES is used to treat breast and prostate cancers. A phosphate derivative of DES [Diethylstilbestrol diphosphate (DES-P)] which is specific to tumor cells consisting alkaline phosphatase enzyme was synthesized and labeled with 99mTc using tin chloride as reducing agent. In vivo biological activity of 99mTc labeled diethylstilbestrol phosphate compound ( 99mTc-DES-P) was examined by biodistribution studies on Wistar Albino rats. Statistical evaluation was performed using SPSS 13 program. The percentage (%) radiolabeling yield of 99mTc-DES-P and quality control studies were done by Thin Layer Radio Chromatography (TLRC). Results showed that, 99mTc-DES-P may be proposed as an imaging agent for ER enriched tumors such as uterus and prostate and their metastases in bones. © 2012 Akadémiai Kiadó.
dc.identifier.DOI-ID10.1007/s10967-012-1755-5
dc.identifier.issn15882780
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/17596
dc.language.isoEnglish
dc.subjectalkaline phosphatase
dc.subjectdiethylstilbestrol phosphate
dc.subjectdiethylstilbestrol phosphate derivative
dc.subjecttechnetium 99m
dc.subjecttin chloride
dc.subjectunclassified drug
dc.subjectanimal experiment
dc.subjectanimal tissue
dc.subjectarticle
dc.subjectcarbon nuclear magnetic resonance
dc.subjectcontrolled study
dc.subjectdistillation
dc.subjectdrug distribution
dc.subjectdrug structure
dc.subjectdrug synthesis
dc.subjectfemale
dc.subjectimaging
dc.subjectin vivo study
dc.subjectisotope labeling
dc.subjectmale
dc.subjectnonhuman
dc.subjectpopulation distribution
dc.subjectpurification
dc.subjectquality control
dc.subjectradioactivity
dc.subjectradiochromatography
dc.subjectrat
dc.subjecttandem mass spectrometry
dc.subjectthin layer chromatography
dc.subjecttissue distribution
dc.titleSynthesis, radiolabeling and in vivo biodistribution of diethylstilbestrol phosphate derivative (DES-P)
dc.typeArticle

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