Comparative morphological differences between umbilical cords from chronic hypertensive and preeclamptic pregnancies

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dc.contributor.authorInan S.
dc.contributor.authorSanci M.
dc.contributor.authorCan D.
dc.contributor.authorVatansever S.
dc.contributor.authorOztekin O.
dc.contributor.authorTinar S.
dc.date.accessioned2024-07-22T08:25:10Z
dc.date.available2024-07-22T08:25:10Z
dc.date.issued2002
dc.description.abstractTo compare morphological changes in the umbilical cords from chronic hypertensive and preeclamptic patients having normal or pathological umbilical artery Doppler ultrasonographic results. Umbilical cords from 34 normotensive, 31 chronic hypertensive and 70 preeclamptic women with normal and abnormal Doppler flow velocity waveforms (FVW) at 35 40 gestational weeks were studied. Morphological changes in the umbilical cords were examined on formalin-fixed, paraffin-embedded sections. The total umbilical cord area, total vessel area, and wall thickness of umbilical vessels were measured in systematic random samples using unbiased stereology methods. An ANOVA test was used for statistical analysis. In the chronic hypertensive and preeclamptic groups with normal Doppler FVW, the thickness of the umbilical cord vessels remained nearly constant, whereas both the total area and the lumen area were reduced. These changes correlate with the histopathological findings, suggesting a mainly vasoconstrictive effect. By contrast, analysis of the preeclamptic group with pathologic Doppler FVW showed a comparable reduction of all parameters of the umbilical cord. Histopathological findings were related to smaller, contracted smooth muscle cells of the vessel wall, which is suggestive of a predominant hypoplastic mechanism. As a result of reduced uteroplacental perfusion, fetal hypoxia and intrauterine growth retardation become un-avoidable in preeclampsia. The histopathological changes in the umbilical cord between the chronic hypertensive and preeclamptic patients depend on the Doppler results. In conclusion, the umbilical artery Doppler FVW indices provide good values for predicting intrauterine growth retardation in preeclamptic patients.
dc.identifier.issn0386300X
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/20287
dc.language.isoEnglish
dc.subjectAdult
dc.subjectBlood Flow Velocity
dc.subjectChronic Disease
dc.subjectFemale
dc.subjectHumans
dc.subjectHypertension
dc.subjectPre-Eclampsia
dc.subjectPregnancy
dc.subjectPregnancy Complications, Cardiovascular
dc.subjectReference Values
dc.subjectRheology
dc.subjectUltrasonography, Doppler
dc.subjectUmbilical Cord
dc.subjectadult
dc.subjectarticle
dc.subjectblood flow velocity
dc.subjectchronic disease
dc.subjectcomparative study
dc.subjectDoppler flowmetry
dc.subjectechography
dc.subjectfemale
dc.subjectflow kinetics
dc.subjecthuman
dc.subjecthypertension
dc.subjectpathology
dc.subjectpreeclampsia
dc.subjectpregnancy
dc.subjectpregnancy complication
dc.subjectreference value
dc.subjectumbilical cord
dc.subjectvascularization
dc.titleComparative morphological differences between umbilical cords from chronic hypertensive and preeclamptic pregnancies
dc.typeArticle

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