The effect of radiolabeled antibiotics on biofilm and microorganism within biofilm
| dc.contributor.author | Avcibasi, U | |
| dc.contributor.author | Demiroglu, H | |
| dc.contributor.author | Sakarya, S | |
| dc.contributor.author | Ünak, P | |
| dc.contributor.author | Tekin, V | |
| dc.contributor.author | Ates, B | |
| dc.date.accessioned | 2025-04-10T10:35:15Z | |
| dc.date.available | 2025-04-10T10:35:15Z | |
| dc.description.abstract | The aim of this study was to investigate the I-131 and I-127 labeled linezolid and moxifloxacin effects of minimum inhibitory concentration, and minimum bactericidal concentration on mature biofilm and microorganism within the biofilm. Linezolid and moxifloxacin were labeled with I-131 and I-127 and chromatography studies were carried out with thin layer radiochromatograpy and high-pressure liquid radiochromatography techniques. Specific activities of radiolabeled LZD and MXF was found to be 53.3 +/- 3.1 and 127.3 +/- 1.1 MBq/A mu mol for [I-131]LZD and 7.6 +/- 0.02 and 55.6 +/- 0.8 MBq/A mu mol for [I-131]MXF, respectively. The minimum inhibitory concentration and Time-Kill of Linezolid and moxifloxacin alone and their I-131 and I-127 labeled forms were tested with a standard strain of meticillin-susceptible StaphylocA +/- ccus aureus. MIC values of LNZ and MXF were 2.96 nmol/mL (1 A mu g/ml) and 0.141 nmol/mL (0.062 A mu g/ml). Time Kills of MXF and LZD were found to be 0.06 and 1 mu g, respectively. Antibiotics labeled with beta-emitting radioactive molecule may be a new theranostics strategy for biofilm infections. | |
| dc.identifier.e-issn | 1588-2780 | |
| dc.identifier.issn | 0236-5731 | |
| dc.identifier.uri | http://hdl.handle.net/20.500.14701/41292 | |
| dc.language.iso | English | |
| dc.title | The effect of radiolabeled antibiotics on biofilm and microorganism within biofilm | |
| dc.type | Article |