Combination of mean platelet volume and the CURB-65 score better predicts 28-day mortality in patients with community-acquired pneumonia

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dc.contributor.authorGolcuk Y.
dc.contributor.authorGolcuk B.
dc.contributor.authorBilge A.
dc.contributor.authorIrik M.
dc.contributor.authorDikmen O.
dc.date.accessioned2024-07-22T08:13:12Z
dc.date.available2024-07-22T08:13:12Z
dc.date.issued2015
dc.description.abstractObjective: This study aims to investigate whether mean platelet volume (MPV) is correlated with the CURB-65 (Confusion, Urea, Respiratory rate, Blood pressure, > 65 years of age) score, and whether a combination of the CURB-65 score with MPV could better predict the 28-day mortality in patients with community-acquired pneumonia (CAP). Methods: This prospective, observational, single-center, and cross-sectional study was conducted at emergency department (ED) between September 1, 2013, and July 31, 2014. All patients underwent follow-up evaluations 28 days after admission. The end point was defined as all-cause mortality. Results: A total of 174 patients (mean age, 66.7 ± 15.8 years; 66.1% men) with CAP were enrolled in this study. All-cause mortality at the 28-day follow-up evaluation was 16.1%. A significant and inverse correlation between MPV and CURB-65 score was found (R = -.58, P <.001). We determined that the optimal MPV cutoff for predicting 28-day mortality at the time of ED admission was 8.55 fL, with a 75.0% sensitivity and a 75.3% specificity. For the prediction of 28-day mortality, the area under the receiver operating characteristic curve was 0.819 (95% confidence interval [CI], 0.740-0.898; P <.001) when the CURB-65 score was used alone, whereas it increased to 0.895 (95% CI, 0.819-0.936; P <.001) with the addition of MPV to the score. Conclusions: Mean platelet volume level is valuable for predicting mortality and the severity of disease among patients with CAP at ED admission. Furthermore, a combination of CURB-65 score and MPV can enhance the predictive accuracy of 28-day mortality. © 2015 Elsevier Inc.
dc.identifier.DOI-ID10.1016/j.ajem.2015.02.001
dc.identifier.issn07356757
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/16295
dc.language.isoEnglish
dc.publisherW.B. Saunders
dc.subjectAged
dc.subjectCause of Death
dc.subjectCommunity-Acquired Infections
dc.subjectCross-Sectional Studies
dc.subjectEmergency Service, Hospital
dc.subjectFemale
dc.subjectHospital Mortality
dc.subjectHumans
dc.subjectMale
dc.subjectMean Platelet Volume
dc.subjectPneumonia
dc.subjectPredictive Value of Tests
dc.subjectProspective Studies
dc.subjectSensitivity and Specificity
dc.subjectSeverity of Illness Index
dc.subjectTurkey
dc.subjectaged
dc.subjectArticle
dc.subjectartificial ventilation
dc.subjectblood cell count
dc.subjectbody temperature
dc.subjectbreathing rate
dc.subjectcommunity acquired pneumonia
dc.subjectconfusion
dc.subjectcross-sectional study
dc.subjectCURB 65 score
dc.subjectdiastolic blood pressure
dc.subjectemergency ward
dc.subjectfemale
dc.subjectfollow up
dc.subjecthemodynamic parameters
dc.subjecthospital admission
dc.subjecthuman
dc.subjectmajor clinical study
dc.subjectmale
dc.subjectmedical history
dc.subjectmortality
dc.subjectobservational study
dc.subjectoxygen saturation
dc.subjectpriority journal
dc.subjectprospective study
dc.subjectrespiratory tract disease assessment
dc.subjectsystolic blood pressure
dc.subjectthrombocyte volume
dc.subjectblood
dc.subjectcause of death
dc.subjectcommunity acquired infection
dc.subjectemergency health service
dc.subjectepidemiology
dc.subjectpneumonia
dc.subjectpredictive value
dc.subjectsensitivity and specificity
dc.subjectseverity of illness index
dc.subjectTurkey
dc.titleCombination of mean platelet volume and the CURB-65 score better predicts 28-day mortality in patients with community-acquired pneumonia
dc.typeArticle

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