Two case reports and a literature review of typical GBS and rare GBS variants associated with COVID-19
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2023
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Abstract
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) emerged in late 2019, and is the infectious agent that caused the coronavirus disease 2019 (COVID-19) pandemic. Although respiratory and gastrointestinal manifestations of SARS-CoV-2 are well defined, the spectrum of neurological involvement is less defined. The classic type of Guillain–Barré syndrome (GBS) progresses over days to weeks and has a monophasic course. Areflexia/hyporeflexia and ascending and symmetrical paralysis are observed clinically in patients. It is an autoimmune process that typically leads to the destruction of myelin after infection. There have been numerous reports of adult patients with the coexistence of GBS disease and active COVID-19 illness, but this number is lacking for children. In this study, we present a literature review of the etiological correlation between SARS-CoV-2 and GBS and describe the cases of two pediatric patients with acute monophasic Guillain–Barré syndrome (GBS) during active COVID-19 infection. © 2023 French Society of Pediatrics
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Adult , Child , COVID-19 , Gastrointestinal Tract , Guillain-Barre Syndrome , Humans , Pandemics , SARS-CoV-2 , C reactive protein , creatine kinase , ferritin , adolescent , Article , autoimmune disease , blood cell count , case report , clinical article , clinical examination , controlled study , coronavirus disease 2019 , electromyography , erythrocyte sedimentation rate , female , Guillain Barre syndrome , human , liver function test , male , muscle strength , myasthenia gravis , nasopharyngeal swab , neurological complication , nuclear magnetic resonance imaging , polymerase chain reaction , sensory analysis , systematic review , adult , child , complication , gastrointestinal tract , Guillain Barre syndrome , pandemic , Severe acute respiratory syndrome coronavirus 2