The effect of propolis extract in experimental chemical corneal injury

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dc.contributor.authorÖztürk F.
dc.contributor.authorKurt E.
dc.contributor.authorÇerçi M.
dc.contributor.authorEmiroǧlu L.
dc.contributor.authorInan U.
dc.contributor.authorTürker M.
dc.contributor.authorIlker S.
dc.date.accessioned2024-07-22T08:25:36Z
dc.date.available2024-07-22T08:25:36Z
dc.date.issued2000
dc.description.abstractPurpose: To investigate the effect of propolis, a natural resin produced by honeybees, in the treatment of alkali-injured rabbit eyes. Method: A corneal alkali burn was induced by applying filter paper immersed in 1 N NaOH on the central axis of the right corneas of 24 rabbits for 30 s. The animals were divided into three treatment groups: group 1 (control) was given 0.3% tobramycin and phosphate-buffered solution; group 2 was treated with antibiotic coverage and topical 1% ethanolic extract of propolis; group 3 received antibiotic coverage and topical 1% dexamethasone. The dexamethasone-treated group was maintained as the positive control. Drugs were instilled 4 times a day for 7 days. The corneal inflammation was evaluated by calculating the average inflammatory index obtained from clinical observation of the ciliary hyperemia, central and peripheral corneal edema at 24 h, 48 h, on day 5 and day 7, before sacrificing the animals. Then, the corneas underwent routine histological examination. Results: The effects of dexamethasone and propolis on healing of injured corneas were similar (p > 0.05) and significantly better than controls at 24 h (p < 0.01, p < 0.05, respectively), and on day 7 (p < 0.05) with respect to the inflammatory index. On histological observation, inflammatory cell infiltration was lower as compared to control in both the dexamethasone and propolis groups (p < 0.001) and similar with each other (p > 0.05). Conclusions: Our study shows that propolis has an anti-inflammatory effect comparable to dexamethasone in chemical corneal injury. Copyright (C) 2000 S. Karger AG, Basel.
dc.identifier.DOI-ID10.1159/000055581
dc.identifier.issn00303747
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/20488
dc.language.isoEnglish
dc.publisherS. Karger AG
dc.subjectalcohol
dc.subjectantibiotic agent
dc.subjectdexamethasone
dc.subjectketamine
dc.subjectoxybuprocaine
dc.subjectp 8904
dc.subjectpentobarbital
dc.subjectphosphate
dc.subjectpropolis
dc.subjectsodium hydroxide
dc.subjecttobramycin
dc.subjectunclassified drug
dc.subjectxylazine
dc.subjectanimal experiment
dc.subjectanimal model
dc.subjectantiinflammatory activity
dc.subjectarticle
dc.subjectcaustic burn
dc.subjectcell infiltration
dc.subjectcontrolled study
dc.subjectcornea edema
dc.subjectcornea injury
dc.subjecthistology
dc.subjecthyperemia
dc.subjectkeratitis
dc.subjectnonhuman
dc.subjectpriority journal
dc.subjectrabbit
dc.subjectwound healing
dc.titleThe effect of propolis extract in experimental chemical corneal injury
dc.typeArticle

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