Relationship of tumor-associated macrophage population detected by CD68 pg-m1, CD68 kp1, and cd163 with latent ebv infection and prognosis in classical hodgkin lymphoma

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dc.contributor.authorMavili H.S.
dc.contributor.authorIsisag A.
dc.contributor.authorTan A.
dc.contributor.authorMiskioglu M.
dc.contributor.authorSaka Baraz L.
dc.contributor.authorNese N.
dc.date.accessioned2024-07-22T08:06:46Z
dc.date.available2024-07-22T08:06:46Z
dc.date.issued2021
dc.description.abstractObjective: To evaluate the quantity of tumor-associated macrophages (TAMs) in cases of Hodgkin Lymphoma of classical type (cHL), and to reveal possible associations between TAM intensity and latent Epstein-Barr virus (EBV) infection, overall survival, progression-free survival, prognostic indices, and clinicopathological parameters. Materials and Methods: A total 46 cases of cHL with complete clinical records were selected and re-evaluated histopathologically. Staining for CD68 (PG-M1; KP1 clones) and CD163 was evaluated and the cut-off values were defined. Also, all cases were evaluated using the chromogen in situ hybridization (CISH) method with EBER (Epstein-Barr virus-encoded RNA) probes for the presence of possible EBV infection. Results: It was found that high expression levels of PG-M1 and high International Prognostic Scores (IPS) were associated with shortened overall survival (p=0.047, p=0.013). Cases with 2 or less areas of nodal region involvement were observed to have longer progression-free survival period (p=0.043). Higher expression levels of CD68 PG-M1, CD68 KP1, and CD163 were found to show significant associations with the presence of some clinical parameters such as the presence of B symptoms, spleen involvement, and the presence of EBV infection. Conclusions: Our findings suggest that increase of PG-M1+ TAM is associated with shortened overall survival, while higher expressions of all immunohistochemical markers are statistically significantly associated with the presence of EBV infection and clinical parameters mentioned above. These findings indicate that highlighting the TAM rate via macrophage markers in cases of cHL could be helpful in determining the prognostic risk groups and the relevant results should be mentioned in pathology reports. © 2021, Federation of Turkish Pathology Societies. All rights reserved.
dc.identifier.DOI-ID10.5146/tjpath.2020.01514
dc.identifier.issn10185615
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/13673
dc.language.isoEnglish
dc.publisherFederation of Turkish Pathology Societies
dc.rightsAll Open Access; Gold Open Access; Green Open Access
dc.subjectAntigens, CD
dc.subjectAntigens, Differentiation, Myelomonocytic
dc.subjectBiomarkers, Tumor
dc.subjectEpstein-Barr Virus Infections
dc.subjectFemale
dc.subjectHerpesvirus 4, Human
dc.subjectHodgkin Disease
dc.subjectHumans
dc.subjectImmunohistochemistry
dc.subjectIn Situ Hybridization
dc.subjectLatent Infection
dc.subjectMale
dc.subjectMiddle Aged
dc.subjectPredictive Value of Tests
dc.subjectProgression-Free Survival
dc.subjectReceptors, Cell Surface
dc.subjectRisk Factors
dc.subjectTime Factors
dc.subjectTumor-Associated Macrophages
dc.subjectbleomycin
dc.subjectCD163 antigen
dc.subjectCD68 antigen
dc.subjectdacarbazine
dc.subjectdoxorubicin
dc.subjectvinblastine
dc.subjectCD163 antigen
dc.subjectCD68 antigen, human
dc.subjectcell surface receptor
dc.subjectdifferentiation antigen
dc.subjectleukocyte antigen
dc.subjecttumor marker
dc.subjectadult
dc.subjectArticle
dc.subjectcancer prognosis
dc.subjectcancer survival
dc.subjectchromogenic in situ hybridization
dc.subjectclassical Hodgkin lymphoma
dc.subjectclinical article
dc.subjectdisease exacerbation
dc.subjectEpstein Barr virus infection
dc.subjectfemale
dc.subjectgene expression
dc.subjecthistopathology
dc.subjecthuman
dc.subjecthuman cell
dc.subjecthuman tissue
dc.subjectimmunohistochemistry
dc.subjectInternational Prognostic Scoring System
dc.subjectlymphocyte depletion Hodgkin lymphoma
dc.subjectmale
dc.subjectmediastinum mass
dc.subjectmiddle aged
dc.subjectmixed cellularity Hodgkin lymphoma
dc.subjectoverall survival
dc.subjectprogression free survival
dc.subjectprotein expression
dc.subjectsurvival time
dc.subjecttumor volume
dc.subjecttumor-associated macrophage
dc.subjectvirus detection
dc.subjectEpstein Barr virus
dc.subjectEpstein Barr virus infection
dc.subjectgenetics
dc.subjectHodgkin disease
dc.subjectimmunology
dc.subjectin situ hybridization
dc.subjectinfection
dc.subjectpathology
dc.subjectpredictive value
dc.subjectrisk factor
dc.subjecttime factor
dc.subjectvirology
dc.titleRelationship of tumor-associated macrophage population detected by CD68 pg-m1, CD68 kp1, and cd163 with latent ebv infection and prognosis in classical hodgkin lymphoma
dc.typeArticle

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