Acute and 28-day repeated dose toxicity evaluations of cold pressed Pinus halepensis Mill. seed oil in mice and rats

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dc.contributor.authorAit Atmane S.
dc.contributor.authorAit Eldjoudi D.
dc.contributor.authorAksoylu Özbek Z.
dc.contributor.authorGünç Ergönül P.
dc.contributor.authorKhettal B.
dc.date.accessioned2024-07-22T08:04:15Z
dc.date.available2024-07-22T08:04:15Z
dc.date.issued2022
dc.description.abstractPinus halepensis Mill. seed (Pinaceae), popularly known as ‘Zgougou’, is widely consumed in the Mediterranean countries and used traditionally in the treatment of some diseases such as bronchitis, rheumatism, infection, and inflammation. The present study aimed to evaluate the oral safety of cold pressed oil of Pinus halepensis Mill. seeds (COPHS) by acute and 28-day repeated dose toxicities studies in Wistar mice and rats, respectively. In the acute toxicity study, oral administration of COPHS to mice did not provoke mortality or any toxic signs at doses up to 5000 mg/kg bw. After administration of COPHS at doses of 250, 500, and 1000 mg/kg bw/day for 28 days, no abnormal changes were observed in body weight, water intake, food consumption, organ weight, blood haematological, serum biochemistry parameters, and histology profile. Furthermore, there was no animal death or any symptom of toxicity in any group during sub-acute toxicity test period. Our findings demonstrate that COPHS is relatively non-toxic and has a large safety margin (>5000 mg/kg). The results of the present research provide basic reference data for food consumption and for future in vivo screening of biological and pharmacological properties of cold pressed oil of Pinus halepensis Mill. seeds. © 2022 Elsevier Inc.
dc.identifier.DOI-ID10.1016/j.yrtph.2022.105191
dc.identifier.issn02732300
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/12622
dc.language.isoEnglish
dc.publisherAcademic Press Inc.
dc.subjectAnimals
dc.subjectMice
dc.subjectPinus
dc.subjectPlant Extracts
dc.subjectPlant Oils
dc.subjectRats
dc.subjectRats, Wistar
dc.subjectSeeds
dc.subjectToxicity Tests, Acute
dc.subjectalanine aminotransferase
dc.subjectalbumin
dc.subjectalkaline phosphatase
dc.subjectaspartate aminotransferase
dc.subjectbilirubin
dc.subjectcholesterol
dc.subjectcreatinine
dc.subjectfatty acid
dc.subjectglucose
dc.subjecthemoglobin
dc.subjectlinoleic acid
dc.subjectoleic acid
dc.subjectprotein
dc.subjectsodium chloride
dc.subjecttriacylglycerol
dc.subjecturea
dc.subjectvegetable oil
dc.subjectplant extract
dc.subjectvegetable oil
dc.subjectacute toxicity
dc.subjectanimal experiment
dc.subjectanimal model
dc.subjectArticle
dc.subjectbasophil
dc.subjectbiochemical analysis
dc.subjectblood biochemistry
dc.subjectblood sampling
dc.subjectbody weight
dc.subjectdrug toxicity
dc.subjecteosinophil
dc.subjecterythrocyte count
dc.subjectfemale
dc.subjectfluid intake
dc.subjectfood intake
dc.subjecthematocrit
dc.subjecthematological parameters
dc.subjecthistology
dc.subjecthistopathology
dc.subjectin vivo study
dc.subjectindustry
dc.subjectLD50
dc.subjectleukocyte
dc.subjectlymphocyte
dc.subjectmale
dc.subjectmean corpuscular hemoglobin
dc.subjectmean corpuscular volume
dc.subjectmonocyte
dc.subjectmorbidity
dc.subjectmortality
dc.subjectmouse
dc.subjectneutrophil
dc.subjectnonhuman
dc.subjectpine
dc.subjectplant seed
dc.subjectrat
dc.subjectsingle drug dose
dc.subjectthrombocyte
dc.subjectvold pressed pinus halepensis mill
dc.subjectanimal
dc.subjectchemistry
dc.subjectplant seed
dc.subjecttoxicity testing
dc.subjectWistar rat
dc.titleAcute and 28-day repeated dose toxicity evaluations of cold pressed Pinus halepensis Mill. seed oil in mice and rats
dc.typeArticle

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