Novel inflammatory targets for immunotherapies in pediatric patients with trichotillomania

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dc.contributor.authorKutuk M.O.
dc.contributor.authorTufan A.E.
dc.contributor.authorKilicaslan F.
dc.contributor.authorMutluer T.
dc.contributor.authorGokcen C.
dc.contributor.authorKaradag M.
dc.contributor.authorYektas C.
dc.contributor.authorKandemir H.
dc.contributor.authorBuber A.
dc.contributor.authorGuler Aksu G.
dc.contributor.authorTopal Z.
dc.contributor.authorGiray A.
dc.contributor.authorCelik F.
dc.contributor.authorAcikbas U.
dc.contributor.authorKutuk O.
dc.date.accessioned2024-07-22T08:07:39Z
dc.date.available2024-07-22T08:07:39Z
dc.date.issued2020
dc.description.abstractImmune dysregulation may be important in the etiology of obsessive-compulsive and related disordersandbody-focusedrepetitivebehaviors, such as Trichotillomania (TTM). The role of inflammation and inflammatory markers in TTM has received relatively little attention. This study was aimed to determine the expression levels of inflammatory markers (i.e. IL-1β, IL-1α, IL-4, IL-6, IL-17, TNF-α and TGF-β) in peripheral blood mononuclear cells of children with TTM and healthy controls and to evaluate their association with clinical variables. Seventy-seven patients with TTM and 107 healthy controls were enrolled in the study. Peripheral blood was collected in standardized conditions. The mean age of patients and controls did not differ significantly (10.8 ± 4.4 and 12.0 ± 3.2 years; respectively). The majority of patients with TTM and controls were females (n = 55, 71.4 % and n = 55, 51.4 %; respectively); with a greater preponderance of females among TTM. Patients with TTM had significantly elevated expression levels of TNF-α, IL-6 and IL-17 compared to controls. However, the expression level of IL-4 was significantly reduced in TTM patients compared to controls. Accordingly, we found a pro-inflammatory state in TTM and those findings may suggest novel treatment options for TTM and further, cross-disciplinary studies focusing on neuro- inflammation in TTM conducted on larger samples are needed. © 2020 Elsevier GmbH
dc.identifier.DOI-ID10.1016/j.imbio.2020.151913
dc.identifier.issn01712985
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/14050
dc.language.isoEnglish
dc.publisherElsevier GmbH
dc.subjectAdolescent
dc.subjectAge Factors
dc.subjectBiomarkers
dc.subjectCase-Control Studies
dc.subjectChild
dc.subjectCytokines
dc.subjectDisease Management
dc.subjectDisease Susceptibility
dc.subjectFemale
dc.subjectHumans
dc.subjectImmunotherapy
dc.subjectInflammation Mediators
dc.subjectMale
dc.subjectPhenotype
dc.subjectSex Factors
dc.subjectTrichotillomania
dc.subjectcytokine
dc.subjectinterleukin 17
dc.subjectinterleukin 1alpha
dc.subjectinterleukin 1beta
dc.subjectinterleukin 4
dc.subjectinterleukin 6
dc.subjecttransforming growth factor beta
dc.subjecttumor necrosis factor
dc.subjectautacoid
dc.subjectbiological marker
dc.subjectcytokine
dc.subjectArticle
dc.subjectcase control study
dc.subjectchild
dc.subjectcontrolled study
dc.subjectcross-sectional study
dc.subjectfemale
dc.subjecthuman
dc.subjecthuman cell
dc.subjectimmunotherapy
dc.subjectinflammation
dc.subjectmajor clinical study
dc.subjectmale
dc.subjectperipheral blood mononuclear cell
dc.subjectpriority journal
dc.subjectprotein expression
dc.subjecttrichotillomania
dc.subjectadolescent
dc.subjectage
dc.subjectblood
dc.subjectdisease management
dc.subjectdisease predisposition
dc.subjectimmunotherapy
dc.subjectmetabolism
dc.subjectphenotype
dc.subjectsex factor
dc.subjecttrichotillomania
dc.titleNovel inflammatory targets for immunotherapies in pediatric patients with trichotillomania
dc.typeArticle

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