Serum lipid and lipoprotein profile in children with iron deficiency anemia

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dc.contributor.authorAydin E.
dc.contributor.authorYiǧitoǧlu M.R.
dc.contributor.authorVurgun N.
dc.contributor.authorGüven H.
dc.contributor.authorIşcan A.
dc.date.accessioned2024-07-22T08:25:36Z
dc.date.available2024-07-22T08:25:36Z
dc.date.issued1999
dc.description.abstractBackground: A close association has been found between serum lipoprotein abnormalities and the risk of atherosclerosis. In adults, high stored body iron, high serum iron concentrations and low iron binding capacity were found to be risk factors for coronary heart disease. Iron-deficient diets have caused contradictory lipid changes in rats. This report investigates the relationships between iron deficiency, macronutrient intake and the serum lipid and lipoprotein profiles in children with iron deficiency anemia (IDA). Methods and Results: Fifty-six children with IDA, aged 3.0±1.3 years and 60 healthy age- and sex-matched controls were evaluated. The mean total cholesterol (TC) and low density lipoprotein cholesterol (LDL-C), lipoprotein (a) levels and LDL-C/high density lipoprotein cholesterol (HDL-C) and TC/HDL- C ratios of the IDA group were significantly lower than those of controls. While there were no differences in triglycerides and apolipoprotein B (apoB) values between patients and controls, apolipoprotein A-1 (apoA-1) and HDL-C levels were higher in the IDA group. Dietary energy, carbohydrates, total fat and protein intakes of the IDA group were lower than those of controls. After oral iron supplementation, the lipoprotein profile of patients with IDA became similar to controls. In the multivariate analysis, while energy was taken as a covariate, them was no difference in the lipid profile of patients and controls. Conclusions: Patients with IDA are also deficient in macronutrients. The low atherogenic serum lipid profile of IDA is not a direct result of iron deficiency itself, but related to decreased energy and protein intakes.
dc.identifier.DOI-ID10.1046/j.1442-200X.1999.4121036.x
dc.identifier.issn13288067
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/20492
dc.language.isoEnglish
dc.subjectAnemia, Iron-Deficiency
dc.subjectChild, Preschool
dc.subjectDietary Carbohydrates
dc.subjectDietary Fats
dc.subjectDietary Proteins
dc.subjectFemale
dc.subjectHumans
dc.subjectInfant
dc.subjectLipids
dc.subjectLipoproteins
dc.subjectMale
dc.subjectMatched-Pair Analysis
dc.subjectapolipoprotein a1
dc.subjectapolipoprotein b
dc.subjectcholesterol
dc.subjecthigh density lipoprotein cholesterol
dc.subjectiron
dc.subjectlipid
dc.subjectlipoprotein
dc.subjectlipoprotein a
dc.subjectlow density lipoprotein cholesterol
dc.subjecttriacylglycerol
dc.subjectarticle
dc.subjectatherosclerosis
dc.subjectcaloric intake
dc.subjectchild
dc.subjectcontrolled study
dc.subjectfemale
dc.subjecthuman
dc.subjectiron binding capacity
dc.subjectiron deficiency anemia
dc.subjectiron therapy
dc.subjectischemic heart disease
dc.subjectlipid blood level
dc.subjectmajor clinical study
dc.subjectmale
dc.subjectmalnutrition
dc.subjectpriority journal
dc.subjectprotein intake
dc.titleSerum lipid and lipoprotein profile in children with iron deficiency anemia
dc.typeArticle

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