Prognostic factors in patients with cerebral sinus venous thrombosis presenting with hemorrhage and papilledema

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dc.contributor.authorSarıtaş A.Ş.
dc.contributor.authorBatum M.
dc.contributor.authorAtaç C.
dc.contributor.authorÖztürk Ü.
dc.contributor.authorYılmaz H.
dc.contributor.authorMavioğlu H.
dc.contributor.authorSelçuki D.
dc.contributor.authorAk A.K.
dc.date.accessioned2024-07-22T08:02:18Z
dc.date.available2024-07-22T08:02:18Z
dc.date.issued2023
dc.description.abstractObjective: The thromboinflammatory process is considered to play a role in the pathogenesis and prognosis of cerebral sinus vein thrombosis (CSVT). The purpose of the study was to compare the thromboinflammatory parameters between individuals with CSVT and healty controls. Additionally, the study sought to compare these parameters among CSVT subgroups with and without haemorrhage, as well as with and without papilledema. Furthermore, the investigation also aimed to identify which parameters had a more significant impact on the risk of hemorrhage and the development of papilledema in CSVT. Methods: Thromboinflammatory parameters were compared retrospectively between the CSVT group of 88 patients and 80 age- and sex-matched healthy controls, and in the CSVT subgroups with (n = 35) /without hemorrhage (n = 53) and with (n = 52) /without papilledema (n = 36) after ethics committee approval. In both groups, parameters contributing to the risk of hemorrhage and papilledema development were determined by univariate and multivariate analyses. Results: Regarding the risk of hemorrhage in CSVT patients, the most significant factors included hematocrit of <30.2 (%), mean platelet volume of ≤8.9 fL, neutrophil count of >5600, and hsCRP of >9 mg/L. Regarding the risk of papilledema development, the most important risk factors were age of ≤49, presence of vomiting, presence of blurred vision, HDL of >47 mg/dL, and D-dimer of >178 ng/mL. Conclusion: It was suggested that evaluating serum thromboinflammatory parameters, as well as demographic characteristics and neurological examination findings, had a critical role regarding prognosis and predictive factors in CSVT. © 2023
dc.identifier.DOI-ID10.1016/j.clineuro.2023.108013
dc.identifier.issn03038467
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/11776
dc.language.isoEnglish
dc.publisherElsevier B.V.
dc.subjectHemorrhage
dc.subjectHumans
dc.subjectPapilledema
dc.subjectPrognosis
dc.subjectRetrospective Studies
dc.subjectRisk Factors
dc.subjectSinus Thrombosis, Intracranial
dc.subjectVenous Thrombosis
dc.subjectC reactive protein
dc.subjectD dimer
dc.subjectfibrinogen
dc.subjecthemoglobin
dc.subjecthigh density lipoprotein
dc.subjectoral contraceptive agent
dc.subjectadult
dc.subjectage
dc.subjectArticle
dc.subjectbleeding
dc.subjectblurred vision
dc.subjectcase control study
dc.subjectcerebral sinus thrombosis
dc.subjectcontrolled study
dc.subjectdemographics
dc.subjectdiagnostic accuracy
dc.subjectdiplopia
dc.subjectfemale
dc.subjectgender
dc.subjecthematocrit
dc.subjecthemiparesis
dc.subjecthuman
dc.subjectlymphocyte
dc.subjectmajor clinical study
dc.subjectmale
dc.subjectmean corpuscular volume
dc.subjectmean platelet volume
dc.subjectmonocyte count
dc.subjectmultivariate analysis
dc.subjectneutrophil
dc.subjectneutrophil count
dc.subjectpapilledema
dc.subjectpathogenesis
dc.subjectplatelet count
dc.subjectpredictive value
dc.subjectprocedures
dc.subjectprognosis
dc.subjectpuerperium
dc.subjectrisk factor
dc.subjectseizure
dc.subjectunivariate analysis
dc.subjectvomiting
dc.subjectYouden index
dc.subjectbleeding
dc.subjectcerebral sinus thrombosis
dc.subjectcomplication
dc.subjectdiagnostic imaging
dc.subjectretrospective study
dc.subjectvein thrombosis
dc.titlePrognostic factors in patients with cerebral sinus venous thrombosis presenting with hemorrhage and papilledema
dc.typeArticle

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